Liusov V A, Kharchenko V I, Istomina I A, Rifai M A, Evsikov E M
Kardiologiia. 1983 Apr;23(4):59-65.
The parameters of water-electrolyte metabolism and central hemodynamics were studied in 44 patients with essential hypertension (stage II-III) after 3-week treatment with sympatholytics and diuretics. Patients with hyperkinetic type of hemocirculation had a sodium lack at the stage of stable hypertension, therefore the diuretic treatment is not indicated for such patients. The treatment with the diuretic oxodolin was accompanied by the decrease in the peripheral resistance of blood vessels, in sodium metabolism and its extracellular fraction, and by the increase of the deposit sodium fraction. The elevation of the renin-angiotensin system activity due to the diuretic therapy did not influence the blood pressure level and the central hemodynamics parameters.
对44例原发性高血压（II - III期）患者在使用交感神经阻滞剂和利尿剂治疗3周后，进行了水电解质代谢和中心血流动力学参数的研究。血液动力学为高动力型的患者在稳定高血压阶段存在缺钠情况，因此这类患者不适合进行利尿治疗。使用利尿剂氧多利治疗时，伴有血管外周阻力降低、钠代谢及其细胞外部分减少以及沉积钠部分增加。利尿剂治疗导致的肾素 - 血管紧张素系统活性升高并未影响血压水平和中心血流动力学参数。
