Levin T N, Rigden L B, Nielsen L H, Moore H L, Twardowski Z J, Khanna R, Nolph K D
Kidney Int. 1987 Mar;31(3):731-5. doi: 10.1038/ki.1987.59.
It has been suggested that filtration pressure equilibrium could occur in peritoneal capillaries during peritoneal dialysis with very hypertonic exchanges. Rats were exposed to peritoneal dialysis solutions using 16 ml instillations, 30 minute cycles, and dextrose concentrations from 1.4 to 20 g%. There was a plateau in ultrafiltration per exchange at mean osmotic gradients above 360 mOsm/kg H2O near 12.5 ml/ex (0.42 ml/min). The findings are also compatible with filtration pressure equilibrium predictions at an effective capillary plasma flow of 0.84 ml/min and a filtration fraction near 50%. Studies with cardiovascular drugs (norepinephrine i.v., nitroprusside i.p., and dobutamine i.v.) showed no effects on the maximum ultrafiltration rates. This might indicate that flow is rather fixed because of known microcirculatory effects of solutions themselves.
有人提出，在使用高渗交换液进行腹膜透析时，腹膜毛细血管中可能会出现滤过压力平衡。对大鼠进行腹膜透析，每次注入16毫升透析液，每30分钟循环一次，葡萄糖浓度为1.4%至20%。在平均渗透梯度高于360 mOsm/kg H2O时，每次交换的超滤量出现平台期，接近12.5毫升/次（0.42毫升/分钟）。这些发现也与有效毛细血管血浆流量为0.84毫升/分钟且滤过分数接近50%时的滤过压力平衡预测结果相符。使用心血管药物（静脉注射去甲肾上腺素、腹腔注射硝普钠和静脉注射多巴酚丁胺）的研究表明，这些药物对最大超滤率没有影响。这可能表明，由于溶液本身已知的微循环效应，血流量相当固定。
