Grzegorzewska A E, Antoniewicz K
Department of Nephrology, Karol Marcinkowski University School of Medical Sciences, Poznan, Poland.
Adv Perit Dial. 1995;11:28-32.
Effective peritoneal capillary blood flow (EPBF) was evaluated by calculating the diffusive mass transport coefficient of carbon dioxide during intermittent peritoneal dialysis (IPD) performed with the intraperitoneal administration of sodium nitroprusside (NP), chlorpromazine (CP), or isoproterenol (IP) in the doses 5, 2.5, and 0.5 mg/L, respectively. Peritoneal transfer rates of substances of different molecular size and charge were simultaneously examined and compared with EPBF. EPBF (mL/min) was 220 +/- 40 (+/- SEM) for NP (n = 11), 224 +/- 29 for CP (n = 10), and 243 +/- 35 for IP (n = 10). These values did not differ significantly from those obtained during dialysis without drugs (223 +/- 22 mL/min, n = 20). NP, CP, and IP did not cause any significant changes in peritoneal transfer of carbon dioxide. Transfer rates of bicarbonate and total carbon dioxide were increased only with NP. All drugs enhanced the peritoneal removal of sodium, potassium, urea, and uric acid. Total protein loss was enhanced by all drugs except IP. With statistically similar EPBF during dialysis, the augmenting effect of NP and IP on small solute removal was the most pronounced. These results indicate that EPBF is not a major factor in the changes in peritoneal transfer rates during dialysis performed with NP, CP, or IP.
通过计算在分别以5 mg/L、2.5 mg/L和0.5 mg/L的剂量腹腔内给予硝普钠（NP）、氯丙嗪（CP）或异丙肾上腺素（IP）进行间歇性腹膜透析（IPD）期间二氧化碳的扩散质量传输系数，评估有效腹膜毛细血管血流量（EPBF）。同时检测不同分子大小和电荷的物质的腹膜转运率，并与EPBF进行比较。NP组（n = 11）的EPBF（mL/min）为220±40（±SEM），CP组（n = 10）为224±29，IP组（n = 10）为243±35。这些值与无药物透析期间获得的值（223±22 mL/min，n = 20）无显著差异。NP、CP和IP均未引起二氧化碳腹膜转运的任何显著变化。仅NP使碳酸氢盐和总二氧化碳的转运率增加。所有药物均增强了钠、钾、尿素和尿酸的腹膜清除。除IP外，所有药物均增加了总蛋白丢失。在透析期间EPBF在统计学上相似的情况下，NP和IP对小溶质清除的增强作用最为明显。这些结果表明，EPBF不是NP、CP或IP透析期间腹膜转运率变化的主要因素。
