Nechifor Gheorghe, Grosu Alexandra Raluca, Ferencz Dinu Andreea, Tanczos Szidonia-Katalin, Goran Alexandru, Grosu Vlad-Alexandru, Bungău Simona Gabriela, Păncescu Florentina Mihaela, Albu Paul Constantin, Nechifor Aurelia Cristina
Analytical Chemistry and Environmental Engineering Department, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Department of Bioengineering, University Sapientia of Miercurea-Ciuc, 500104 Miercurea-Ciuc, Romania.
Membranes (Basel). 2022 May 27;12(6):557. doi: 10.3390/membranes12060557.
The bio-medical benefits of silver ions and 10-undecenoic acid in various chemical-pharmaceutical preparations are indisputable, thus justifying numerous research studies on delayed and/or controlled release. This paper presents the effect of the polymer matrix in the simultaneous release of silver ions and 10-undecenoic acid in an aqueous medium of controlled pH and ionic strength. The study took into consideration polymeric matrices consisting of cellulose acetate (CA) and polysulfone (PSf), which were impregnated with oxide nanoparticles containing silver and 10-undecenoic acid. The studied oxide nanoparticles are nanoparticles of iron and silver oxides obtained by an accessible electrochemical method. The obtained results show that silver can be released, simultaneously with 10-undecenoic acid, from an impregnated polymeric membrane, at concentrations that ensure the biocidal and fungicidal capacity. Concentrations of active substances can be controlled by choosing the polymer matrix or, in some cases, by changing the pH of the target medium. In the studied case, higher concentrations of silver ions are released from the polysulfone matrix, while higher concentrations of 10-undecenoic acid are released from the cellulose acetate matrix. The results of the study show that a correlation can be established between the two released target substances, which is dependent on the solubility of the organic compound in the aqueous medium and the interaction of this compound with the silver ions. The ability of 10-undecenoic acid to interact with the silver ion, both through the carboxyl and alkene groups, contributes to the increase in the content of the silver ions transported in the aqueous medium.
银离子和10-十一碳烯酸在各种化学药物制剂中的生物医学益处是无可争议的，因此有理由对延迟释放和/或控释进行大量研究。本文介绍了聚合物基质在可控pH值和离子强度的水介质中对银离子和10-十一碳烯酸同时释放的影响。该研究考虑了由醋酸纤维素（CA）和聚砜（PSf）组成的聚合物基质，这些基质浸渍了含有银和10-十一碳烯酸的氧化物纳米颗粒。所研究的氧化物纳米颗粒是通过一种可行的电化学方法获得的铁和银的氧化物纳米颗粒。所得结果表明，银可以与10-十一碳烯酸同时从浸渍的聚合物膜中释放出来，其浓度可确保杀菌和杀真菌能力。活性物质的浓度可以通过选择聚合物基质来控制，在某些情况下，也可以通过改变目标介质的pH值来控制。在所研究的案例中，聚砜基质释放出更高浓度的银离子，而醋酸纤维素基质释放出更高浓度的10-十一碳烯酸。研究结果表明，两种释放的目标物质之间可以建立一种相关性，这取决于有机化合物在水介质中的溶解度以及该化合物与银离子的相互作用。10-十一碳烯酸通过羧基和烯烃基团与银离子相互作用的能力，有助于增加在水介质中运输的银离子含量。
