Suzhou Key Laboratory of Nanotechnology and Biomedicine, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China.
Angew Chem Int Ed Engl. 2022 Sep 5;61(36):e202208422. doi: 10.1002/anie.202208422. Epub 2022 Jul 25.
A novel bacteria-based drug delivery system, termed "Trojan nanobacteria system", has been developed in which nanoagents are internalized into engineered bacteria through bacteria-specific maltodextrin (MD) transporters. Compared to the method of attaching nanoagents to bacterial surfaces, this Trojan system features higher payloads and better stability. In cancer therapy, Trojan nanobacteria can specifically discriminate the tumor region and then penetrate deep tumor tissues. Once in the tumor, the Trojan nanobacteria systems are able to destroy deep tumor tissues due to the combined effects of antitumor protein expression (e.g., tumor necrosis factor-α, TNF-α) and photothermal properties.
一种新型的基于细菌的药物输送系统，称为“木马纳米细菌系统”，已经被开发出来，其中纳米试剂通过细菌特异性的麦芽糖（MD）转运蛋白被内化到工程细菌中。与将纳米试剂附着在细菌表面的方法相比，这种木马系统具有更高的载药量和更好的稳定性。在癌症治疗中，木马纳米细菌可以特异性地识别肿瘤区域，然后穿透深部肿瘤组织。一旦进入肿瘤，木马纳米细菌系统由于抗肿瘤蛋白表达（例如肿瘤坏死因子-α，TNF-α）和光热特性的共同作用，能够破坏深部肿瘤组织。
