Wang Xiaocheng, Sun Yazhi, Wangpraseurt Daniel
Department of NanoEngineering University of California San Diego San Diego California USA.
Scripps Institution of Oceanography University of California San Diego San Diego California USA.
Smart Med. 2023 Mar 10;2(2):e20220041. doi: 10.1002/SMMD.20220041. eCollection 2023 May.
Engineered biohybrids have recently emerged as innovative biomimetic platforms for cancer therapeutic applications. Particularly, engineered photoresponsive biohybrids hold tremendous potential against tumors due to their intriguing biomimetic properties, photoresponsive ability, and enhanced biotherapeutic functions. In this review, the design principles of engineered photoresponsive biohybrids and their latest progresses for tumor therapy are summarized. Representative engineered photoresponsive biohybrids are highlighted including biomolecules-associated, cell membrane-based, eukaryotic cell-based, bacteria-based, and algae-based photoresponsive biohybrids. Representative tumor therapeutic modalities of the engineered photoresponsive biohybrids are presented, including photothermal therapy, photodynamic therapy, synergistic therapy, and tumor therapy combined with tissue regeneration. Moreover, the challenges and future perspectives of these photoresponsive biohybrids for clinical practice are discussed.
工程化生物杂交体最近已成为用于癌症治疗应用的创新仿生平台。特别是，工程化光响应生物杂交体因其引人入胜的仿生特性、光响应能力和增强的生物治疗功能而在对抗肿瘤方面具有巨大潜力。在这篇综述中，总结了工程化光响应生物杂交体的设计原理及其在肿瘤治疗方面的最新进展。重点介绍了具有代表性的工程化光响应生物杂交体，包括与生物分子相关的、基于细胞膜的、基于真核细胞的、基于细菌的和基于藻类的光响应生物杂交体。介绍了工程化光响应生物杂交体的代表性肿瘤治疗方式，包括光热疗法、光动力疗法、协同疗法以及与组织再生相结合的肿瘤治疗。此外，还讨论了这些光响应生物杂交体在临床实践中面临的挑战和未来前景。
