农场卫生条件改变生长猪粪便代谢物谱。
Sanitary Conditions on the Farm Alters Fecal Metabolite Profile in Growing Pigs.
作者信息
Kar Soumya K, Te Pas Marinus F W, Kruijt Leo, Vervoort Jacques J M, Jansman Alfons J M, Schokker Dirkjan
机构信息
Animal Nutrition, Wageningen Livestock Research, Wageningen University & Research, 6708 WD Wageningen, The Netherlands.
Animal Breeding & Genomics, Wageningen Livestock Research, Wageningen University & Research, 6708 WD Wageningen, The Netherlands.
出版信息
Metabolites. 2022 Jun 11;12(6):538. doi: 10.3390/metabo12060538.
The aim of this study was to use fecal metabolite profiling to evaluate the effects of contrasting sanitary conditions and the associated subclinical health status of pigs. We analyzed fecal metabolite profiles by nuclear magnetic resonance (1H NMR) from pigs aged 14 and 22 weeks. Pigs kept under low and high sanitary conditions differed in fecal metabolites related to the degradation of dietary starch, metabolism of the gut microbiome, and degradation of components of animal (host) origin. The metabolites that differed significantly (FDR < 0.1) were from metabolic processes involved in either maintaining nutrient digestive capacity, including purine metabolism, energy metabolism, bile acid breakdown and recycling, or immune system metabolism. The results show that the fecal metabolite profiles reflect the sanitary conditions under which the pigs are kept. The fecal metabolite profiles closely resembled the profiles of metabolites found in the colon of pigs. Fecal valerate and kynurenic acid could potentially be used as “non-invasive” biomarkers of immune or inflammatory status that could form the basis for monitoring subclinical health status in pigs.
本研究的目的是利用粪便代谢物谱来评估不同卫生条件及猪的相关亚临床健康状况的影响。我们通过核磁共振（1H NMR）分析了14周龄和22周龄猪的粪便代谢物谱。饲养在低卫生条件和高卫生条件下的猪，其与膳食淀粉降解、肠道微生物群代谢以及动物（宿主）源性成分降解相关的粪便代谢物存在差异。差异显著（FDR < 0.1）的代谢物来自参与维持营养消化能力的代谢过程，包括嘌呤代谢、能量代谢、胆汁酸分解和循环，或免疫系统代谢。结果表明，粪便代谢物谱反映了猪的饲养卫生条件。粪便代谢物谱与猪结肠中发现的代谢物谱非常相似。粪便戊酸和犬尿酸有可能用作免疫或炎症状态的“非侵入性”生物标志物，可为监测猪的亚临床健康状况奠定基础。
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