Asklepios Clinic North-Ochsenzoll, Asklepios Campus Hamburg, Medical Faculty, Semmelweis University, 22419 Hamburg, Germany.
Dell Medical School, University of Texas at Austin, Austin, TX 78712, USA.
Toxins (Basel). 2022 May 31;14(6):383. doi: 10.3390/toxins14060383.
Injection of botulinum toxin (BoNT) into the glabellar region of the face is a novel therapeutic approach in the treatment of depression. This treatment method has several advantages, including few side effects and a long-lasting, depot-like effect. Here we review the clinical and experimental evidence for the antidepressant effect of BoNT injections as well as the theoretical background and possible mechanisms of action. Moreover, we provide practical instructions for the safe and effective application of BoNT in the treatment of depression. Finally, we describe the current status of the clinical development of BoNT as an antidepressant and give an outlook on its potential future role in the management of mental disorders.
将肉毒杆菌毒素（BoNT）注射到面部的皱眉肌区域是治疗抑郁症的一种新的治疗方法。这种治疗方法有几个优点，包括副作用少，且具有长效、类似储存库的效果。在这里，我们回顾了 BoNT 注射治疗抑郁症的临床和实验证据，以及其理论背景和可能的作用机制。此外，我们还提供了 BoNT 安全有效治疗抑郁症的实用指南。最后，我们描述了 BoNT 作为抗抑郁药的临床开发现状，并展望了其在精神障碍治疗中的潜在未来作用。
