玉米赤霉烯酮安全性研究进展述评。
Research Progress of Safety of Zearalenone: A Review.
机构信息
Key Laboratory of Precision Nutrition and Food Quality, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Key Laboratory of Safety Assessment of Genetically Modified Organism (Food Safety), Ministry of Agriculture and Rural Affairs of the China, Beijing 100083, China.
出版信息
Toxins (Basel). 2022 Jun 2;14(6):386. doi: 10.3390/toxins14060386.
Zearalenone, a mycotoxin produced by fungi of the genus , widely exists in animal feed and human food. The structure of zearalenone is similar to estrogen, so it mainly has estrogenic effects on various organisms. Products contaminated with zearalenone can pose risks to animals and humans. Therefore, it is imperative to carry out toxicological research on zearalenone and evaluate its risk to human health. This paper briefly introduces the production, physical, and chemical properties of zearalenone and the research progress of its toxicity kinetics, focusing on its genetic toxicity, reproductive toxicity, hepatotoxicity, immunotoxicity, carcinogenicity, endocrine interference, and its impact on intestinal health. Finally, the progress of the risk assessment of human exposure is summarized to provide a reference for the follow-up study of zearalenone.
玉米赤霉烯酮，一种真菌属产生的霉菌毒素，广泛存在于动物饲料和人类食品中。玉米赤霉烯酮的结构与雌激素相似，因此主要对各种生物体具有雌激素作用。受玉米赤霉烯酮污染的产品会对动物和人类构成威胁。因此，开展玉米赤霉烯酮的毒理学研究并评估其对人类健康的风险迫在眉睫。本文简要介绍了玉米赤霉烯酮的产生、物理和化学性质以及其毒性动力学的研究进展，重点介绍了其遗传毒性、生殖毒性、肝毒性、免疫毒性、致癌性、内分泌干扰以及对肠道健康的影响。最后，总结了人类接触风险评估的进展，为后续玉米赤霉烯酮的研究提供参考。
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