Thomas T, Lorino C, Ferrara J J
J Surg Oncol. 1987 May;35(1):70-4. doi: 10.1002/jso.2930350117.
Fibromatosis is an uncommon, relatively benign though locally infiltrating neoplasm consisting of well-differentiated fibroblasts surrounded by collagen bundles. The majority of the literature suggests that prevention of local recurrence mandates wide (en bloc) excision. Few more than a dozen cases of primary breast fibromatosis have been reported. Herein the clinical characteristics, diagnostic evaluation, and therapeutic options are presented. Management should be based upon principles utilized for extra-mammary primary disease-en bloc resection. This may require total mastectomy and removal of pectoralis major muscle. Breast reconstruction should be deferred for a minimum of 3 years, during which time the majority of recurrences will have become manifest.
纤维瘤病是一种罕见的、相对良性但具有局部浸润性的肿瘤,由被胶原束包围的分化良好的成纤维细胞组成。大多数文献表明,预防局部复发需要进行广泛(整块)切除。报道的原发性乳腺纤维瘤病病例不超过十几例。本文介绍了其临床特征、诊断评估和治疗选择。治疗应基于用于乳腺外原发性疾病的整块切除原则。这可能需要全乳切除和胸大肌切除。乳房重建应推迟至少3年,在此期间大多数复发将会显现。