Laham A, Claperon N, Durussel J J, Fattal E, Delattre J, Puisieux F, Couvreur P, Rossignol P
Life Sci. 1987 May 18;40(20):2011-6. doi: 10.1016/0024-3205(87)90292-x.
ATP was entrapped inside negatively charged liposomes composed of sulfatide, in order to improve its penetration into the brain and to reduce its degradation into other tissues. These liposomes were prepared according to an original method allowing a satisfying stability of the formulation. Liposomally entrapped ATP was administered intracerebroventricularly to rats submitted to brain ischemic episodes by both carotid artery clamping and systemic blood pressure lowering (during 3 minutes every 15 minutes). Such treatment importantly increases the number of ischemic episodes before brain silence appeared. So, this paper allows new perspectives in the administration of drugs into the brain.
为了提高ATP进入大脑的能力并减少其在其他组织中的降解，将ATP包裹在由硫脂组成的带负电荷的脂质体内。这些脂质体是根据一种能使制剂具有令人满意稳定性的原始方法制备的。将脂质体包裹的ATP经脑室内注射给通过夹闭双侧颈动脉和降低全身血压（每15分钟3分钟）诱导脑缺血发作的大鼠。这种治疗显著增加了脑电静息出现前的缺血发作次数。因此，本文为向大脑给药提供了新的视角。
