Laham A, Claperon N, Durussel J J, Fattal E, Delattre J, Puisieux F, Couvreur P, Rossignol P
Laboratoire de Pharmacie Galénique et de Biopharmacie, UA CNRS, Université de Paris XI, Chatenay-Malabry, France.
J Chromatogr. 1988 May 25;440:455-8. doi: 10.1016/s0021-9673(00)94549-7.
Liposomally entrapped adenosine triphosphate (ATP) was administered intracerebroventricularly and intracarotidally to rats subjected to brain ischaemic episodes by clamping of the carotid arteries and lowering of the systemic blood pressure. It was observed that, when entrapped in liposomes, ATP greatly increased the number of ischaemic episodes before brain electrical silence and death. The results open new perspectives in brain ATP supply, which will potentially be useful in human resuscitation from deep brain hypoergic states.
通过夹闭颈动脉和降低体循环血压使大鼠经历脑缺血发作，然后将脂质体包裹的三磷酸腺苷（ATP）经脑室和颈动脉给予这些大鼠。观察到，当ATP被包裹在脂质体中时，它极大地增加了脑电沉默和死亡前缺血发作的次数。这些结果为脑ATP供应开辟了新的前景，这可能对人类从深度脑低能状态复苏有用。
