• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

维生素D对慢性病的多重影响：从减少脂质过氧化到临床研究的最新证据

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.

作者信息

Berretta Massimiliano, Quagliariello Vincenzo, Bignucolo Alessia, Facchini Sergio, Maurea Nicola, Di Francia Raffaele, Fiorica Francesco, Sharifi Saman, Bressan Silvia, Richter Sara N, Camozzi Valentina, Rinaldi Luca, Scaroni Carla, Montopoli Monica

机构信息

Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.

Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80121 Naples, Italy.

出版信息

Antioxidants (Basel). 2022 May 30;11(6):1090. doi: 10.3390/antiox11061090.

DOI:10.3390/antiox11061090
PMID:35739987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9220017/
Abstract

BACKGROUND

Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent.

METHODS

A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health.

RESULTS

In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases.

CONCLUSIONS

Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

摘要

背景

维生素D对人体具有多种有益作用，包括对神经元、免疫和骨骼稳态以及心血管功能的调节。近期研究将维生素D与癌细胞的生长和存活联系起来，但关于该主题的荟萃分析结果往往并不一致。

方法

对PubMed数据库和临床试验注册库进行系统检索，以识别所有潜在相关的英文科学论文，这些论文包含有关维生素D对人类健康影响的原创研究文章。

结果

在本综述中，我们分析了维生素D对急性和慢性疾病的抗氧化和抗炎作用，尤其关注癌症、免疫相关疾病、心肌病（包括心力衰竭、心律失常和动脉粥样硬化）以及传染病。

结论

维生素D可显著降低参与慢性心脏代谢疾病和癌症发生、发展及复发的促氧化全身和组织生物标志物水平。本综述的整体情况为针对癌症、传染病、神经退行性疾病和心血管疾病患者进行口服维生素D补充的新随机对照试验提供了依据，旨在降低疾病复发风险并改善生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/ebf39fdbff74/antioxidants-11-01090-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/c59947db5b50/antioxidants-11-01090-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/785b188867f2/antioxidants-11-01090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/dbf5b5efedf6/antioxidants-11-01090-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/e0f87a3ece66/antioxidants-11-01090-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/ebf39fdbff74/antioxidants-11-01090-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/c59947db5b50/antioxidants-11-01090-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/785b188867f2/antioxidants-11-01090-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/dbf5b5efedf6/antioxidants-11-01090-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/e0f87a3ece66/antioxidants-11-01090-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68ab/9220017/ebf39fdbff74/antioxidants-11-01090-g005.jpg

相似文献

1
The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.维生素D对慢性病的多重影响：从减少脂质过氧化到临床研究的最新证据
Antioxidants (Basel). 2022 May 30;11(6):1090. doi: 10.3390/antiox11061090.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区，服用抗叶酸抗疟药物的人群中，叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Vitamin D and Calcium: A Systematic Review of Health Outcomes (Update).维生素 D 和钙：健康结果的系统评价（更新）。
Evid Rep Technol Assess (Full Rep). 2014 Sep(217):1-929. doi: 10.23970/AHRQEPCERTA217.
4
Vitamin D supplementation for sickle cell disease.镰状细胞病的维生素D补充治疗
Cochrane Database Syst Rev. 2017 Jan 20;1(1):CD010858. doi: 10.1002/14651858.CD010858.pub2.
5
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.一项评估胆钙化醇补充对桥本甲状腺炎自身免疫可能作用的前瞻性研究。
J Assoc Physicians India. 2023 Jan;71(1):1.
6
The future of Cochrane Neonatal.考克兰新生儿协作网的未来。
Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12.
7
Vitamin D supplementation for sickle cell disease.镰状细胞病的维生素D补充治疗
Cochrane Database Syst Rev. 2020 May 28;5(5):CD010858. doi: 10.1002/14651858.CD010858.pub3.
8
9
Vitamin D supplementation for chronic liver diseases in adults.成人慢性肝病的维生素D补充治疗
Cochrane Database Syst Rev. 2017 Nov 3;11(11):CD011564. doi: 10.1002/14651858.CD011564.pub2.
10
Vitamin D and calcium: a systematic review of health outcomes.维生素D与钙：健康结局的系统评价
Evid Rep Technol Assess (Full Rep). 2009 Aug(183):1-420.

引用本文的文献

1
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.植物源化合物的抗炎作用与慢性病预防：从分子机制到应用
Int J Mol Sci. 2025 May 28;26(11):5206. doi: 10.3390/ijms26115206.
2
Multidisciplinary Integrative Medicine Approach for Cancer Patients: A Multicenter Retrospective Study.癌症患者的多学科综合医学方法：一项多中心回顾性研究。
Nutrients. 2025 Mar 13;17(6):1012. doi: 10.3390/nu17061012.
3
Vitamin D: Beyond Traditional Roles-Insights into Its Biochemical Pathways and Physiological Impacts.

本文引用的文献

1
Vitamin D Impacts on Skeletal Muscle Dysfunction in Patients with COPD Promoting Mitochondrial Health.维生素D对慢性阻塞性肺疾病患者骨骼肌功能障碍的影响：促进线粒体健康
Biomedicines. 2022 Apr 14;10(4):898. doi: 10.3390/biomedicines10040898.
2
Nuclear receptor activation shapes spatial genome organization essential for gene expression control: lessons learned from the vitamin D receptor.核受体激活塑造了空间基因组组织，对于基因表达调控至关重要：从维生素 D 受体中得到的启示。
Nucleic Acids Res. 2022 Apr 22;50(7):3745-3763. doi: 10.1093/nar/gkac178.
3
Interplay between Maternal and Neonatal Vitamin D Deficiency and Vitamin-D-Related Gene Polymorphism with Neonatal Birth Anthropometry.
维生素D：超越传统作用——对其生化途径和生理影响的深入了解
Nutrients. 2025 Feb 26;17(5):803. doi: 10.3390/nu17050803.
4
Impact of Vitamin D Levels on Progression-Free Survival and Response to Neoadjuvant Chemotherapy in Breast Cancer Patients: A Systematic Review and Meta-Analysis.维生素D水平对乳腺癌患者无进展生存期及新辅助化疗反应的影响：一项系统评价与Meta分析
Cancers (Basel). 2024 Dec 17;16(24):4206. doi: 10.3390/cancers16244206.
5
Role of Vitamin D in Oral Lichen Planus: A Case Control Study.维生素 D 在口腔扁平苔藓中的作用：一项病例对照研究。
Nutrients. 2024 Aug 19;16(16):2761. doi: 10.3390/nu16162761.
6
The Role of Mannitol and Vitamin D in Ovarian Ischemia/Reperfusion Injury in Rats with Acute Abdominal.甘露醇和维生素D在急性腹部大鼠卵巢缺血/再灌注损伤中的作用
Curr Issues Mol Biol. 2024 Aug 15;46(8):8903-8913. doi: 10.3390/cimb46080526.
7
Potential Advantages of a Well-balanced Nutrition Regimen for People Living with Human Immunodeficiency Virus Type -1.针对感染1型人类免疫缺陷病毒的人群，均衡营养方案的潜在益处。
J AIDS HIV Treat. 2024;6(1):11-27. doi: 10.33696/aids.6.048.
8
Circulating vitamin D level before initiating chemotherapy impacts on the time-to-outcome in metastatic colorectal cancer patients: systematic review and meta-analysis.起始化疗前循环维生素 D 水平对转移性结直肠癌患者结局时间的影响：系统评价和荟萃分析。
J Transl Med. 2024 Jan 30;22(1):119. doi: 10.1186/s12967-024-04889-2.
9
Vitamin D: An Overview of Gene Regulation, Ranging from Metabolism to Genomic Effects.维生素D：从代谢到基因组效应的基因调控概述
Genes (Basel). 2023 Aug 25;14(9):1691. doi: 10.3390/genes14091691.
10
Vitamin D receptor and binding protein genes variants in patients with migraine.偏头痛患者的维生素 D 受体和结合蛋白基因变异。
Ann Clin Transl Neurol. 2023 Oct;10(10):1824-1832. doi: 10.1002/acn3.51872. Epub 2023 Aug 8.
母胎维生素 D 缺乏与维生素 D 相关基因多态性与新生儿出生人体测量学的相互作用。
Nutrients. 2022 Jan 27;14(3):564. doi: 10.3390/nu14030564.
4
Diet, Sun, Physical Activity and Vitamin D Status in Children with Inflammatory Bowel Disease.饮食、阳光、体力活动与炎症性肠病患儿的维生素 D 状态。
Nutrients. 2022 Feb 28;14(5):1029. doi: 10.3390/nu14051029.
5
The Effects of Vitamin D Application on NaF-Induced Cytotoxicity in Osteoblast Cells (hFOB 1.19).维生素D应用对氟化钠诱导的成骨细胞（hFOB 1.19）细胞毒性的影响
Biol Trace Elem Res. 2023 Feb;201(2):698-705. doi: 10.1007/s12011-022-03177-8. Epub 2022 Mar 10.
6
Effect of oral cholecalciferol in a murine model of celiac disease: A dose ranging study.口服胆钙化醇在乳糜泻小鼠模型中的作用：一项剂量范围研究。
J Steroid Biochem Mol Biol. 2022 Jun;220:106083. doi: 10.1016/j.jsbmb.2022.106083. Epub 2022 Mar 4.
7
Synergy of sarcopenia and vitamin D deficiency in vertebral osteoporotic fractures in rheumatoid arthritis.类风湿关节炎患者椎体骨质疏松性骨折中肌肉减少症和维生素 D 缺乏的协同作用。
Clin Rheumatol. 2022 Jul;41(7):1979-1987. doi: 10.1007/s10067-022-06125-y. Epub 2022 Mar 6.
8
Vitamin D Receptor Genetic Variations May Associate with the Risk of Developing Late Fracture-Related Infection in the Chinese Han Population.维生素 D 受体基因变异可能与汉族人群发生晚期骨折相关感染的风险相关。
J Immunol Res. 2022 Feb 10;2022:9025354. doi: 10.1155/2022/9025354. eCollection 2022.
9
Severe Vitamin D Deficiency Is Strongly Associated with Liver Dysfunction and Disease Severity in Hepatitis B Virus Related Cirrhosis and Liver Failure Patients.严重维生素 D 缺乏与乙型肝炎病毒相关肝硬化和肝功能衰竭患者的肝功能障碍和疾病严重程度密切相关。
J Nutr Sci Vitaminol (Tokyo). 2022;68(1):16-22. doi: 10.3177/jnsv.68.16.
10
Vitamin D3 promotes autophagy in THP-1 cells infected with .维生素D3促进感染了……的THP-1细胞中的自噬。 （原文中“infected with”后面内容缺失）
Exp Ther Med. 2022 Mar;23(3):240. doi: 10.3892/etm.2022.11165. Epub 2022 Jan 25.