维生素D对慢性病的多重影响：从减少脂质过氧化到临床研究的最新证据
The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies.
作者信息
Berretta Massimiliano, Quagliariello Vincenzo, Bignucolo Alessia, Facchini Sergio, Maurea Nicola, Di Francia Raffaele, Fiorica Francesco, Sharifi Saman, Bressan Silvia, Richter Sara N, Camozzi Valentina, Rinaldi Luca, Scaroni Carla, Montopoli Monica
机构信息
Department of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Division of Cardiology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, 80121 Naples, Italy.
出版信息
Antioxidants (Basel). 2022 May 30;11(6):1090. doi: 10.3390/antiox11061090.
BACKGROUND
Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent.
METHODS
A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health.
RESULTS
In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases.
CONCLUSIONS
Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.
背景
维生素D对人体具有多种有益作用，包括对神经元、免疫和骨骼稳态以及心血管功能的调节。近期研究将维生素D与癌细胞的生长和存活联系起来，但关于该主题的荟萃分析结果往往并不一致。
方法
对PubMed数据库和临床试验注册库进行系统检索，以识别所有潜在相关的英文科学论文，这些论文包含有关维生素D对人类健康影响的原创研究文章。
结果
在本综述中，我们分析了维生素D对急性和慢性疾病的抗氧化和抗炎作用，尤其关注癌症、免疫相关疾病、心肌病（包括心力衰竭、心律失常和动脉粥样硬化）以及传染病。
结论
维生素D可显著降低参与慢性心脏代谢疾病和癌症发生、发展及复发的促氧化全身和组织生物标志物水平。本综述的整体情况为针对癌症、传染病、神经退行性疾病和心血管疾病患者进行口服维生素D补充的新随机对照试验提供了依据，旨在降低疾病复发风险并改善生活质量。
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