Alharbi Hend F, Algonaiman Raya, Barakat Hassan
Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Buraydah 51452, Saudi Arabia.
Department of Food Technology, Faculty of Agriculture, Benha University, Moshtohor 13736, Egypt.
Antioxidants (Basel). 2022 Jun 6;11(6):1122. doi: 10.3390/antiox11061122.
The ameliorative and antioxidative stress effects of probiotic-enriched fermented oat (FOE) or fermented oat with honey (HFOE) extracts on streptozotocin-induced diabetes in rats were examined. The total phenolic content (TPC) and antioxidant activity (AOA) were increased in FOE and HFOE after 72 h of fermentation, and γ-aminobutyric acid (GABA) reached 7.35 mg 100 g in FOE and 8.49 mg 100 g in HFOE. The β-glucan levels were slightly decreased to 2.45 g 100 g DW in FOE and 2.63 g 100 g DW in HFOE. The antidiabetic and hypolipidemic properties of FOE and HFOE were studied in a designed animal model with seven treated groups for 6 weeks. Groups were treated as follows: group 1 (negative group, NR) and group 2 (diabetic rats, DR) were administered 7 mL distilled water orally per day; group 3 (DR + MET) rats were orally administered 50 mg standard drug Metformin kg daily; group 4 (DR + FOE1) diabetic rats were orally administered 3.5 mL FOE daily; group 5 (DR + FOE2) rats were orally administered 7 mL FOE daily; group 6 (DR + HFOE1) rats were orally administered 3.5 mL HFOE daily; and group 7 (DR + HFOE2) rats were orally administered 7 mL HFOE daily. The HFOE at the high dose had a synergistic effect, lowering random blood glucose (RBG) and fasting blood glucose (FBG). The hypolipidemic potential of HFOE at the high dose was indicated by significant reductions in triglycerides (TG), total cholesterol (CHO), high- and low-density lipoproteins (HDL and LDL), and very-low-density lipoproteins (VLDL). In addition, 7 mL of HFOE improved liver and kidney function more effectively than other fermented extracts or Metformin. As well as the antioxidant enzyme activity, reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malonaldehyde (MDA) were significantly enhanced after the administration of HFOE at 7 mL by 68.6%, 71.5%, 55.69%, and 15.98%, respectively, compared to the DR group. In conclusion, administration of -fermented oats supplemented with honey demonstrated antidiabetic effects and a potential approach for controlling glucose levels and lipid profiles, and protecting against oxidative stress.
研究了富含益生菌的发酵燕麦（FOE）或蜂蜜发酵燕麦（HFOE）提取物对链脲佐菌素诱导的大鼠糖尿病的改善和抗氧化应激作用。发酵72小时后，FOE和HFOE中的总酚含量（TPC）和抗氧化活性（AOA）增加，FOE中的γ-氨基丁酸（GABA）达到7.35毫克/100克，HFOE中的γ-氨基丁酸达到8.49毫克/100克。FOE中的β-葡聚糖水平略有下降至2.45克/100克干重，HFOE中的β-葡聚糖水平为2.63克/100克干重。在一个设计的动物模型中，对七个治疗组进行了6周的研究，以研究FOE和HFOE的抗糖尿病和降血脂特性。分组如下：第1组（阴性组，NR）和第2组（糖尿病大鼠，DR）每天口服7毫升蒸馏水；第3组（DR + MET）大鼠每天口服50毫克标准药物二甲双胍/千克；第4组（DR + FOE1）糖尿病大鼠每天口服3.5毫升FOE；第5组（DR + FOE2）大鼠每天口服7毫升FOE；第6组（DR + HFOE1）大鼠每天口服3.5毫升HFOE；第7组（DR + HFOE2）大鼠每天口服7毫升HFOE。高剂量的HFOE具有协同作用，可降低随机血糖（RBG）和空腹血糖（FBG）。高剂量HFOE的降血脂潜力表现为甘油三酯（TG）、总胆固醇（CHO）、高密度和低密度脂蛋白（HDL和LDL）以及极低密度脂蛋白（VLDL）显著降低。此外，7毫升HFOE比其他发酵提取物或二甲双胍更有效地改善了肝脏和肾脏功能。与DR组相比，给予7毫升HFOE后，抗氧化酶活性、还原型谷胱甘肽（GSH）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和丙二醛（MDA）分别显著提高了68.6%、71.5%、55.69%和15.98%。总之，补充蜂蜜的发酵燕麦具有抗糖尿病作用，是控制血糖水平和血脂谱以及预防氧化应激的一种潜在方法。
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