Adhikari Radhika, Shiwakoti Saugat, Ko Ju-Young, Dhakal Bikalpa, Park Sin-Hee, Choi Ik Jun, Kim Hyun Jung, Oak Min-Ho
College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun 58554, Jeonnam, Korea.
Catholic Research Institute for Intractable Cardiovascular Disease (CRID), College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Antioxidants (Basel). 2022 Jun 14;11(6):1169. doi: 10.3390/antiox11061169.
Calcific aortic valve stenosis (CAVS) is the most prevalent heart valvular disease worldwide and a slowly progressive disorder characterized by thickening of the aortic valve, calcification, and subsequent heart failure. Valvular calcification is an active cell regulation process in which valvular interstitial cells involve phenotypic conversion into osteoblasts/chondrocytes-like cells. The underlying pathophysiology is complicated, and there have been no pharmacological treatments for CAVS to date. Recent studies have suggested that an increase in oxidative stress is the major trigger of CAVS, and natural antioxidants could ameliorate the detrimental effects of reactive oxygen species in the pathogenesis of CAVS. It is imperative to review the current findings regarding the role of natural antioxidants in CAVS, as they can be a promising therapeutic approach for managing CAVS, a disorder currently without effective treatment. This review summarizes the current findings on molecular mechanisms associated with oxidative stress in the development of valvular calcification and discusses the protective roles of natural antioxidants in the prevention and treatment of CAVS.
钙化性主动脉瓣狭窄（CAVS）是全球最常见的心脏瓣膜疾病，是一种缓慢进展的疾病，其特征为主动脉瓣增厚、钙化以及随后发生的心力衰竭。瓣膜钙化是一个活跃的细胞调节过程，其中瓣膜间质细胞会发生表型转化，变为成骨细胞/软骨细胞样细胞。其潜在的病理生理学机制较为复杂，迄今为止尚无针对CAVS的药物治疗方法。最近的研究表明，氧化应激增加是CAVS的主要触发因素，天然抗氧化剂可以减轻活性氧在CAVS发病机制中的有害作用。鉴于天然抗氧化剂可能是管理目前尚无有效治疗方法的CAVS的一种有前景的治疗方法，因此有必要回顾一下目前关于天然抗氧化剂在CAVS中作用的研究结果。本综述总结了目前关于瓣膜钙化发展过程中与氧化应激相关分子机制的研究结果，并讨论了天然抗氧化剂在预防和治疗CAVS中的保护作用。
