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钙化性主动脉瓣疾病的血流动力学和病理生理机制

The Haemodynamic and Pathophysiological Mechanisms of Calcific Aortic Valve Disease.

作者信息

Hanna Lydia, Armour Chlöe, Xu Xiao Yun, Gibbs Richard

机构信息

Imperial Vascular Unit, St Mary's Hospital, Imperial College Healthcare NHS Trust, London W2 1NY, UK.

Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

出版信息

Biomedicines. 2022 Jun 3;10(6):1317. doi: 10.3390/biomedicines10061317.

DOI:10.3390/biomedicines10061317
PMID:35740339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9220142/
Abstract

The aortic valve (AoV) is the outflow valve for the left heart [...].

摘要

主动脉瓣（AoV）是左心的流出阀[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/226273b4e354/biomedicines-10-01317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/1eaac38b9e19/biomedicines-10-01317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/ce5fdf671ed6/biomedicines-10-01317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/449f9fafe300/biomedicines-10-01317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/226273b4e354/biomedicines-10-01317-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/1eaac38b9e19/biomedicines-10-01317-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/ce5fdf671ed6/biomedicines-10-01317-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/449f9fafe300/biomedicines-10-01317-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c61d/9220142/226273b4e354/biomedicines-10-01317-g004.jpg

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Aging (Albany NY). 2021 May 11;13(9):12710-12732. doi: 10.18632/aging.202942.
2
Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial.地舒单抗或阿仑膦酸对主动脉瓣狭窄进展的影响：一项双盲随机对照试验。
Circulation. 2021 Jun 22;143(25):2418-2427. doi: 10.1161/CIRCULATIONAHA.121.053708. Epub 2021 Apr 29.
3
Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers.
人工心脏瓣膜的计算机模拟试验复制了评估人工瓣叶疲劳寿命的方法，以超越体外测试和传统临床试验。
Biomedicines. 2025 May 7;13(5):1135. doi: 10.3390/biomedicines13051135.
4
Integrin-Linked Kinase Expression in Human Valve Endothelial Cells Plays a Protective Role in Calcific Aortic Valve Disease.整合素连接激酶在人瓣膜内皮细胞中的表达在钙化性主动脉瓣疾病中发挥保护作用。
Antioxidants (Basel). 2022 Aug 31;11(9):1736. doi: 10.3390/antiox11091736.
严重主动脉瓣狭窄的代谢组学研究揭示一氧化氮合成中间体为最具特征性的标志物。
Int J Mol Sci. 2021 Mar 30;22(7):3569. doi: 10.3390/ijms22073569.
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Side-specific valvular endothelial-interstitial cell mechano-communication via cadherin-11.瓣叶特异性的黏着蛋白-11 介导的瓣膜内皮间质细胞力学通讯
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