Lauriola Michele, D'Onofrio Grazia, la Torre Annamaria, Ciccone Filomena, Germano Carmela, Cascavilla Leandro, Greco Antonio
Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Clinical Psychology Service, Health Department, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Biomedicines. 2022 Jun 10;10(6):1381. doi: 10.3390/biomedicines10061381.
Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, affective, and functional assessment scales. MTA was evaluated from 0 (no atrophy) to 4 (severe atrophy). The homocysteine serum was set to two levels: between 0 and 10 µmol/L, and >10 µmol/L. The cholesterol and glycemia blood concentrations were measured. Hypertension and atrial fibrillation presence/absence were collected. A total of 14 patients were MTA 0, 44 patients were MTA 1, 63 patients were MTA 2, 79 patients were MTA 3, and 39 patients were MTA 4. Cognitive (p < 0.0001) and functional (p < 0.0001) parameters decreased according to the MTA severity. According to the diagnosis distribution, AD patient percentages increased by MTA severity (p < 0.0001). In addition, the homocysteine levels increased according to MTA severity (p < 0.0001). Depression (p < 0.0001) and anxiety (p = 0.001) increased according to MTA severity. This study encourages and supports the potential role of MTA score and CT scan in the field of neurodegenerative disorder research and diagnosis.
我们的研究旨在调查通过计算机断层扫描（CT）评估的内侧颞叶萎缩（MTA）评分与功能损害、认知缺陷及心理行为障碍严重程度之间的关系。总体而言，对239名患者（男性92名，女性147名；平均年龄79.3±6.8岁）进行了认知、神经精神、情感和功能评估量表测评。MTA的评估范围为0（无萎缩）至4（严重萎缩）。将血清同型半胱氨酸设定为两个水平：0至10µmol/L之间以及>10µmol/L。测量了胆固醇和血糖的血浓度。收集了高血压和房颤的有无情况。共有14名患者MTA为0，44名患者MTA为1，63名患者MTA为2，79名患者MTA为3，39名患者MTA为4。认知参数（p<0.0001）和功能参数（p<0.0001）随MTA严重程度增加而降低。根据诊断分布，AD患者百分比随MTA严重程度增加（p<0.0001）。此外，同型半胱氨酸水平随MTA严重程度增加（p<0.0001）。抑郁（p<0.0001）和焦虑（p=0.001）随MTA严重程度增加。本研究鼓励并支持MTA评分和CT扫描在神经退行性疾病研究和诊断领域的潜在作用。
