Hakim Maliha, Islam Mahmudul, Hossain Mohammad Akter, Uddin Mohammad Nur, Baqui Murshed, Hasan Mashfiqul, Islam Mohammad Nazrul, Mamun Mim Tanzila, Mamun Alif Al, Ranjan Redoy, Yusuf Md Abdullah, Kawnayn Ghulam
Neurology, National Institute of Neurosciences and Hospital, Dhaka, BGD.
Neurology, Dhaka Medical College, Dhaka, BGD.
Cureus. 2024 Jul 31;16(7):e65833. doi: 10.7759/cureus.65833. eCollection 2024 Jul.
Alzheimer's disease (AD) patients suffer from cognitive dysfunction. This study assessed the structural magnetic resonance imaging (MRI) scoring among Alzheimer's patients (age ≥18 years) to correlate with dementia severity according to mini-mental state exam (MMSE) scores.
This cross-sectional study evaluated Bangladeshi adult AD patients from January 2018 to December 2022 who attended with subjective memory complaints and fulfilled the diagnostic and statistical manual of mental disorders criteria (DSM 5) for diagnosing dementia. The medial temporal lobe atrophy (MTA) and Koedam's score of the atrophy were measured utilising the 1.5 and 3 Tesla Magnetom symphony MRI systems.
Of the 62 patients enrolled, the majority (39 cases; 62.9%) were aged over 60 years. Males were more predominant than females, with a male-to-female ratio of 2.6:1, and the moderate MMSE group consisted of 35.6% males and 64.7% females (P = 0.01). Further, MTA score severity is paradoxically associated with the MMSE score (P = 0.005). Additionally, we found a statistically significant negative correlation between the severity of the MMSE and only MTA scores (r = -0.350; 95% CI -0.551 to -0.110; P = 0.005).
Structural magnetic resonance imaging among Alzheimer's patients is significantly correlated with the severity of dementia as per mini-mental state exam scores.
阿尔茨海默病（AD）患者存在认知功能障碍。本研究评估了年龄≥18岁的阿尔茨海默病患者的结构磁共振成像（MRI）评分，以根据简易精神状态检查表（MMSE）评分与痴呆严重程度进行关联。
这项横断面研究评估了2018年1月至2022年12月期间因主观记忆问题就诊且符合精神障碍诊断与统计手册标准（DSM-5）中痴呆诊断标准的孟加拉国成年AD患者。使用1.5和3特斯拉Magnetom symphony MRI系统测量内侧颞叶萎缩（MTA）及萎缩的Koedam评分。
在纳入的62例患者中，大多数（39例；62.9%）年龄超过60岁。男性比女性更占优势，男女比例为2.6:1，中度MMSE组中男性占35.6%，女性占64.7%（P = 0.01）。此外，MTA评分严重程度与MMSE评分呈反常相关（P = 0.005）。此外，我们发现MMSE严重程度与仅MTA评分之间存在统计学显著的负相关（r = -0.350；95%CI -0.551至-0.110；P = 0.005）。
根据简易精神状态检查表评分，阿尔茨海默病患者的结构磁共振成像与痴呆严重程度显著相关。
