Research and Clinical Alzheimer's Disease Center, CMRR, CHU Toulouse, IHU HealthAge, Toulouse, France.
Maintain Aging Research team, CERPOP, Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France.
Alzheimers Dement. 2024 Jul;20(7):4692-4701. doi: 10.1002/alz.13902. Epub 2024 Jun 14.
The mechanisms linking mild behavioral impairment (MBI) and Alzheimer's disease (AD) have been insufficiently explored, with conflicting results regarding tau protein and few data on other metabolic markers. We aimed to evaluate the longitudinal association of the MBI domains and a spectrum of plasma biomarkers.
Our study is a secondary analysis of data from NOLAN. The longitudinal association of the MBI domains with plasma biomarkers, including pTau181, was tested using adjusted linear mixed-effects models.
The sample comprised 359 participants (60% female, mean age: 78.3, standard deviation: 0.3 years). After 1 year, the MBI domain of abnormal perception was associated with steeper increases in plasma pTau181. Abnormal perception, decreased motivation, and impulse dyscontrol were associated with homocysteine or insulin dysregulation.
Apart from the association with plasma pTau181, our results suggest that MBI might also represent metabolic dysregulation, probably contributing to dementia transition among older adults with subjective cognitive decline or mild cognitive impairment.
Mild behavioral impairment (MBI) psychosis was associated with steeper increases in plasma p. pTau could be a pharmacological target to treat agitation and psychosis symptoms. MBI domains were linked to metabolic dysregulation involving insulin and homocysteine.
轻度行为障碍（MBI）与阿尔茨海默病（AD）之间的联系机制尚未得到充分探索，tau 蛋白方面的结果相互矛盾，其他代谢标志物的数据也很少。我们旨在评估 MBI 各领域与一系列血浆生物标志物的纵向关联。
我们的研究是对 NOLAN 数据的二次分析。使用调整后的线性混合效应模型检验 MBI 各领域与包括 pTau181 在内的血浆生物标志物的纵向关联。
样本包括 359 名参与者（60%为女性，平均年龄：78.3 岁，标准差：0.3 年）。1 年后，异常知觉的 MBI 域与血浆 pTau181 的增加呈正相关。异常知觉、动机减退和冲动控制障碍与同型半胱氨酸或胰岛素失调有关。
除了与血浆 pTau181 的关联外，我们的结果还表明，MBI 可能也代表代谢失调，可能会导致有主观认知下降或轻度认知障碍的老年人向痴呆转变。
MBI 精神病与血浆 p 增加呈正相关。 pTau 可能是治疗激越和精神病症状的药物靶点。MBI 各领域与涉及胰岛素和同型半胱氨酸的代谢失调有关。
