Badowska-Kozakiewicz Anna, Fudalej Marta, Kwaśniewska Daria, Durlik Marek, Nasierowska-Guttmejer Anna, Mormul Agata, Włoszek Emilia, Czerw Aleksandra, Banaś Tomasz, Deptała Andrzej
Department of Cancer Prevention, Medical University of Warsaw, 01-445 Warsaw, Poland.
Department of Oncology and Haematology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
Cancers (Basel). 2022 Jun 8;14(12):2840. doi: 10.3390/cancers14122840.
pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer-related deaths with increasing incidence and link to the onset of diabetes mellitus (DM). The aim of this study is to describe the prevalence of DM among patients with the diagnosis of PDAC, analyse the association between the occurrence of DM and clinicopathological factors, and detect variables influencing overall survival.
a retrospective analysis of medical records was performed. The patients were divided into non-DM ( = 101) and DM ( = 74) groups. Statistical analysis with the usage of appropriate tests was conducted.
Patients in the groups of DM and NODM had significantly longer median OS than the non-DM group. Nodal involvement, tumour location, level of CEA, CRP and CRP/lymphocytes ratio were significantly associated with OS among patients with any type of DM. Neutropenia was less frequently observed in the DM group.
DM is prevalent among patients with pancreatic cancer. In our study, patients with DM receiving palliative chemotherapy had significantly higher median OS than those without DM. The increased comprehension of the mechanisms of the relationship between DM and pancreatic cancer needs further research, which might provide avenues for the development of novel preventive and therapeutic strategies.
胰腺导管腺癌（PDAC）是癌症相关死亡的第七大主要原因，其发病率不断上升，且与糖尿病（DM）的发病有关。本研究的目的是描述PDAC诊断患者中DM的患病率，分析DM的发生与临床病理因素之间的关联，并检测影响总生存期的变量。
对病历进行回顾性分析。将患者分为非DM组（n = 101）和DM组（n = 74）。使用适当的检验进行统计分析。
DM组和非DM组患者的中位总生存期均显著长于非DM组。在任何类型的DM患者中，淋巴结受累、肿瘤位置、癌胚抗原（CEA）水平、C反应蛋白（CRP）水平和CRP/淋巴细胞比值与总生存期显著相关。DM组中性粒细胞减少的发生率较低。
DM在胰腺癌患者中很常见。在我们的研究中，接受姑息化疗的DM患者的中位总生存期显著高于未患DM的患者。需要进一步研究以加深对DM与胰腺癌之间关系机制的理解，这可能为开发新的预防和治疗策略提供途径。
