Fudalej Marta, Kwaśniewska Daria, Nurzyński Paweł, Badowska-Kozakiewicz Anna, Mękal Dominika, Czerw Aleksandra, Sygit Katarzyna, Deptała Andrzej
Department of Oncology Propaedeutics, Medical University of Warsaw, 01-445 Warsaw, Poland.
Department of Oncology, Central Clinical Hospital of the Ministry of Interior and Administration, 02-507 Warsaw, Poland.
Cancers (Basel). 2023 Apr 17;15(8):2327. doi: 10.3390/cancers15082327.
Pancreatic cancer (PC) is the seventh leading cause of cancer death across the world. Poor prognosis of PC is associated with several factors, such as diagnosis at an advanced stage, early distant metastases, and remarkable resistance to most conventional treatment options. The pathogenesis of PC seems to be significantly more complicated than originally assumed, and findings in other solid tumours cannot be extrapolated to this malignancy. To develop effective treatment schemes prolonging patient survival, a multidirectional approach encompassing different aspects of the cancer is needed. Particular directions have been established; however, further studies bringing them all together and connecting the strengths of each therapy are needed. This review summarises the current literature and provides an overview of new or emerging therapeutic strategies for the more effective management of metastatic PC.
胰腺癌（PC）是全球癌症死亡的第七大主要原因。PC的预后不良与多种因素有关，如晚期诊断、早期远处转移以及对大多数传统治疗方案的显著耐药性。PC的发病机制似乎比最初设想的要复杂得多，其他实体瘤的研究结果不能外推到这种恶性肿瘤。为了制定延长患者生存期的有效治疗方案，需要一种涵盖癌症不同方面的多方向方法。已经确定了特定的方向；然而，还需要进一步的研究将它们整合在一起，并结合每种疗法的优势。本综述总结了当前的文献，并概述了用于更有效治疗转移性PC的新的或正在出现的治疗策略。
