a Department of Medical and Clinical Psychology , Tilburg University , Tilburg , The Netherlands.
b Department of Research , Netherlands Comprehensive Cancer Organisation (IKNL) , Utrecht , The Netherlands.
Acta Oncol. 2018 Oct;57(10):1381-1391. doi: 10.1080/0284186X.2018.1481293. Epub 2018 Jun 18.
Cancer and its treatment have an influence on health-related quality of life (HRQOL). Normative data could help to interpret HRQOL among cancer patients. Our aim was to generate longitudinal normative data based on sex, age and morbidity for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.
The QLQ-C30 and the Self-administered Comorbidity Questionnaire were administered to a representative panel of the Dutch-speaking population in the Netherlands in 2009 (n = 1743), 2010 (n = 2050), 2011 (n = 2040), 2012 (n = 2194) and 2013 (n = 2333).
Regarding sex, at baseline, women scored statistically significant and clinically relevant worse on fatigue, pain and insomnia compared to men. Regarding age groups and sex, HRQoL was lower among the older age groups in men and women. For men, at baseline, significant and clinically relevant age differences were found on physical, role and cognitive functioning, global QOL scale, fatigue, pain and dyspnea. The change over 5 years was larger for older age groups. For women, at baseline, significant and clinically relevant age differences were found on physical functioning, role functioning, nausea/vomiting, pain, dyspnea and insomnia. Those without self-reported morbidities reported a better HRQoL compared to those with morbidities. Among those who completed five assessments, the summary scale scores were stable over time, were higher in men than in women, and higher in younger compared to older age groups.
Although HRQoL remains relatively stable over time, HRQoL data needs to be interpreted with care as many confounding factors can have an impact on HRQOL. Our data (which is freely available) can aid in the interpretation of QLQ-C30 scores and can help increase our understanding of the influence of age, sex, time and morbid conditions on HRQoL among cancer patients.
癌症及其治疗会对健康相关生活质量（HRQOL）产生影响。常模数据有助于解释癌症患者的 HRQOL。我们的目的是基于性别、年龄和发病情况为欧洲癌症研究与治疗组织（EORTC）QLQ-C30 问卷生成纵向常模数据。
2009 年（n=1743）、2010 年（n=2050）、2011 年（n=2040）、2012 年（n=2194）和 2013 年（n=2333），在荷兰的荷兰语人群中，使用 QLQ-C30 问卷和自我报告合并症问卷进行代表性面板调查。
关于性别，在基线时，与男性相比，女性在疲劳、疼痛和失眠方面的评分在统计学上显著且具有临床意义。关于年龄组和性别，男性和女性的年龄较大的年龄组的 HRQoL 较低。对于男性，在基线时，在身体功能、角色功能和认知功能、总体生活质量量表、疲劳、疼痛和呼吸困难方面，发现了具有统计学意义和临床意义的年龄差异。5 年内的变化在年龄较大的年龄组中更大。对于女性，在基线时，在身体功能、角色功能、恶心/呕吐、疼痛、呼吸困难和失眠方面，发现了具有统计学意义和临床意义的年龄差异。与有合并症的人相比，没有报告合并症的人报告的 HRQoL 更好。在完成五次评估的人群中，综合量表评分随时间稳定，男性高于女性，年轻人群高于老年人群。
尽管 HRQoL 随时间相对稳定，但 HRQoL 数据需要谨慎解释，因为许多混杂因素会对 HRQoL 产生影响。我们的数据（可免费获得）可帮助解释 QLQ-C30 评分，并有助于提高我们对年龄、性别、时间和合并症对癌症患者 HRQoL 影响的理解。
