Department of Pediatrics, Division of Hematology-Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Cells. 2022 Jun 10;11(12):1887. doi: 10.3390/cells11121887.
Members of the caspase family are well known for their roles in the initiation and execution of cell death. Due to their function in the removal of damaged cells that could otherwise become malignant, caspases are important players in the DNA damage response (DDR), a network of pathways that prevent genomic instability. However, emerging evidence of caspases positively or negatively impacting the accumulation of DNA damage in the absence of cell death demonstrates that caspases play a role in the DDR that is independent of their role in apoptosis. This review highlights the apoptotic and non-apoptotic roles of caspases in the DDR and how they can impact genomic stability and cancer treatment.
细胞凋亡蛋白酶家族成员以其在细胞死亡的启动和执行中的作用而闻名。由于它们在清除受损细胞方面的作用，这些细胞否则可能会癌变，因此细胞凋亡蛋白酶在 DNA 损伤反应 (DDR) 中是重要的参与者，DDR 是一个防止基因组不稳定性的途径网络。然而，越来越多的证据表明，细胞凋亡蛋白酶在没有细胞死亡的情况下，积极或消极地影响 DNA 损伤的积累，这表明细胞凋亡蛋白酶在 DDR 中发挥作用，而不依赖于它们在细胞凋亡中的作用。本综述强调了细胞凋亡蛋白酶在 DDR 中的凋亡和非凋亡作用，以及它们如何影响基因组稳定性和癌症治疗。
