Clinical Pharmacology & Precision Medicine, William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK.
Cells. 2022 Jun 15;11(12):1932. doi: 10.3390/cells11121932.
Cell responses to changes in their redox state are significantly mediated by reversible oxido-reductive post-translational modifications of proteins, potentially altering their activities or interactions. These modifications are important for the homeostatic responses of cells to environmental changes that alter their redox state. Such redox regulatory mechanisms not only operate to maintain health, but can become dysregulated and contribute to pathophysiology. In this review, we focus on the redox control of soluble epoxide hydrolase (sEH), which is widely expressed, including in blood vessels and cardiomyocytes. We review the different types of oxidative modifications that regulate sEH and how they may alter cardiovascular physiology and affect disease progression during stress.
细胞对其氧化还原状态变化的反应主要通过蛋白质的可逆氧化还原翻译后修饰来介导，这可能改变它们的活性或相互作用。这些修饰对于细胞对改变其氧化还原状态的环境变化的稳态反应非常重要。这种氧化还原调节机制不仅用于维持健康，而且可能失调并导致病理生理学。在这篇综述中，我们重点介绍可溶性环氧化物水解酶（sEH）的氧化还原调控，sEH 广泛表达，包括在血管和心肌细胞中。我们回顾了调节 sEH 的不同类型的氧化修饰，以及它们如何改变心血管生理学，并在应激过程中影响疾病进展。
