进展相关基因影响胶质母细胞瘤患者的预后。
The Progression Related Gene Affects the Prognosis of Glioblastoma Patients.
作者信息
Sun Liwei, Yan Tao, Yang Bing
机构信息
Department of Oncology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease, Tianjin Neurosurgical Institute, Tianjin 300350, China.
Department of Pharmacy, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease, Tianjin Neurosurgical Institute, Tianjin 300350, China.
出版信息
Brain Sci. 2022 Jun 11;12(6):767. doi: 10.3390/brainsci12060767.
BACKGROUND
Glioblastoma (GBM) represents the most malignant glioma among astrocytomas and is a lethal form of brain cancer. Many RAB genes are involved in different cancers but (Ras-associated binding 42) is seldom studied in GBM. Our study aimed to explore the role of expression in the development and prognosis of GBM.
METHODS
All GBM patient data were obtained from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases. The relevance of expression to the clinicopathologic characteristics of GBM patients was analyzed. The overall survival (OS) significance was determined using log-rank. Significantly enriched KEGG pathways were screened using gene set enrichment analysis (GSEA).
RESULTS
High expression of was observed in GBM specimens compared with normal samples, which was also verified in cell lines and tissue samples. Elevated expression was correlated with higher GBM histological grade. The prognosis of GBM patients with high expression was worse than those with lower . A total of 35 pathways, such as the P53 pathway, were significantly activated in highly -expressed GBM samples.
CONCLUSIONS
High expression is related to the development of GBM, and is a probable prognostic marker for GBM.
背景
胶质母细胞瘤（GBM）是星形细胞瘤中最恶性的胶质瘤，是一种致命的脑癌形式。许多RAB基因参与不同的癌症，但RAB42（Ras相关结合蛋白42）在GBM中的研究很少。我们的研究旨在探讨RAB42表达在GBM发生发展及预后中的作用。
方法
所有GBM患者数据均来自癌症基因组图谱（TCGA）和中国胶质瘤基因组图谱（CGGA）数据库。分析RAB42表达与GBM患者临床病理特征的相关性。采用对数秩检验确定总生存期（OS）的意义。使用基因集富集分析（GSEA）筛选显著富集的KEGG通路。
结果
与正常样本相比，GBM标本中观察到RAB42高表达，这在细胞系和组织样本中也得到了验证。RAB42表达升高与较高的GBM组织学分级相关。RAB42高表达的GBM患者预后比低表达患者差。在RAB42高表达的GBM样本中，共有35条通路，如P53通路，被显著激活。
结论
RAB42高表达与GBM的发生发展有关，RAB42可能是GBM的一个预后标志物。
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