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小胶质细胞在神经精神疾病和自杀中的作用。

The role of microglia in neuropsychiatric disorders and suicide.

机构信息

Department of Forensic Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2022 Sep;272(6):929-945. doi: 10.1007/s00406-021-01334-z. Epub 2021 Sep 30.

DOI:10.1007/s00406-021-01334-z
PMID:34595576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9388452/
Abstract

This narrative review examines the possible role of microglial cells, first, in neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research on the interactions between microglia, astrocytes and neurons and their involvement in pathophysiological processes of neuropsychiatric disorders is presented. This review focuses on results from postmortem, positron emission tomography (PET) imaging studies, and animal models of schizophrenia and depression. Third, the effects of antipsychotic and antidepressant drug therapy, and of electroconvulsive therapy on microglial cells are explored and the upcoming development of therapeutic drugs targeting microglia is described. Finally, there is a discussion on the role of microglia in the evolutionary progression of human lineage. This view may contribute to a new understanding of neuropsychiatric disorders.

摘要

这篇综述探讨了小胶质细胞的可能作用，首先是在神经炎症中，其次是在精神分裂症、抑郁症和自杀中。本文介绍了最近关于小胶质细胞、星形胶质细胞和神经元之间相互作用及其在神经精神疾病病理生理过程中作用的研究。这篇综述重点介绍了精神分裂症和抑郁症的尸体研究、正电子发射断层扫描（PET）成像研究和动物模型的结果。第三，探讨了抗精神病药和抗抑郁药治疗以及电惊厥治疗对小胶质细胞的影响，并描述了靶向小胶质细胞的治疗药物的未来发展。最后，讨论了小胶质细胞在人类进化过程中的作用。这一观点可能有助于对神经精神疾病有新的认识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b258/9388452/e6292a302fa9/406_2021_1334_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b258/9388452/e02aabc8316b/406_2021_1334_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b258/9388452/e6292a302fa9/406_2021_1334_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b258/9388452/e02aabc8316b/406_2021_1334_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b258/9388452/e6292a302fa9/406_2021_1334_Fig2_HTML.jpg

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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Glutamate and microglia activation as a driver of dendritic apoptosis: a core pathophysiological mechanism to understand schizophrenia.

Transl Psychiatry. 2021-5-6

[2]
Are CB2 Receptors a New Target for Schizophrenia Treatment?

Front Psychiatry. 2020-10-30

[3]
Neuroinflammation as measured by positron emission tomography in patients with recent onset and established schizophrenia: implications for immune pathogenesis.

Mol Psychiatry. 2021-9

[4]
The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia.

Front Pharmacol. 2020-3-31

[5]
Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia.

Front Psychiatry. 2020-3-26

[6]
Lateralization of increased density of Iba1-immunopositive microglial cells in the anterior midcingulate cortex of schizophrenia and bipolar disorder.

Eur Arch Psychiatry Clin Neurosci. 2020-10

[7]
Microglial activation increases cocaine self-administration following adolescent nicotine exposure.

Nat Commun. 2020-1-16

[8]
BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis.

J Neuroinflammation. 2020-1-13

[9]
The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences.

Neurosci Lett. 2019-8-15

[10]
The fetal origins of mental illness.

Am J Obstet Gynecol. 2019-6-15

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