Yang Chen, Tan Youlan, Li Fengzhu, Wang Hongbin, Lin Ying, Lu Fuping, Zhao Huabing
College of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, China.
Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300450, China.
Foods. 2022 Jun 9;11(12):1696. doi: 10.3390/foods11121696.
Exposure to titanium dioxide nanoparticles (TiO NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota.
接触二氧化钛纳米颗粒（TiO NPs）和双酚A（BPA）的情况普遍存在，尤其是通过饮食和其他环境途径。在本研究中，成年C57BL/6J小鼠被暴露于TiO NPs（100毫克/千克）、BPA（0、5和50毫克/千克）或它们的二元混合物中13周。16S rDNA扩增序列分析表明，TiO NPs和BPA共同暴露会改变肠道微生物群；然而，这种改变主要是由TiO NPs引起的。粪便代谢组学分析表明，共同暴露组中有28种代谢物和3条代谢途径发生了改变。本研究首次揭示了TiO NPs和BPA对哺乳动物肠道微生物群落和代谢动态的联合作用，这对人类健康具有重要价值。由于TiO NPs和BPA与肠道微生物群相互作用，它们在肠道中的共存带来了潜在的健康风险。
