Kanwar S S, Walia B N, Ganguly N K, Mahajan R C
Med Microbiol Immunol. 1987;176(2):83-8. doi: 10.1007/BF00200679.
Direct and antibody-dependent, cell-mediated cytotoxic responses exhibited against Giardia lamblia trophozoites by peritoneal macrophages of infected animals were studied. On first exposure, the infection persisted for 30 days and peak cytotoxic responses were noticed on the 20th day post infection. In reinfected animals, peak response was on 10th day and these animals were capable of clearing the infection much faster compared with animals infected for the first time. Macrophages in Giardia infection, therefore, seem to play an important role in providing resistance to infected animals as evident from significant augmentation of their cytotoxic responses in the infected animals.
研究了感染动物腹腔巨噬细胞对蓝氏贾第鞭毛虫滋养体表现出的直接和抗体依赖性细胞介导的细胞毒性反应。初次感染时，感染持续30天，在感染后第20天观察到细胞毒性反应达到峰值。在再次感染的动物中，峰值反应出现在第10天，与初次感染的动物相比，这些动物能够更快地清除感染。因此，贾第虫感染中的巨噬细胞似乎在为感染动物提供抵抗力方面发挥重要作用，这从感染动物中其细胞毒性反应的显著增强可以明显看出。
