小鼠脾脏和肠道淋巴细胞对蓝氏贾第鞭毛虫的直接及抗体依赖性细胞介导的细胞毒性作用
Direct and antibody dependent cell mediated cytotoxicity against Giardia lamblia by splenic and intestinal lymphoid cells in mice.
作者信息
Kanwar S S, Ganguly N K, Walia B N, Mahajan R C
出版信息
Gut. 1986 Jan;27(1):73-7. doi: 10.1136/gut.27.1.73.
Abstract
Direct cytotoxicity and antibody dependent cell mediated cytotoxicity against Giardia lamblia trophozoites exhibited by splenic, intraepithelial and lamina propria lymphocyte populations isolated from G lamblia infected mice were studied. Different patterns of cytotoxicity were found. Intraepithelial lymphocytes showed a direct cytotoxic activity of 20.6 +/- 5.6% before infection. It was significantly higher on the 20th (p less than 0.01) and 30th (p less than 0.05) day postinfection. Lamina propria lymphocytes showed a significantly augmented level of both direct cytotoxicity and antibody dependent cell mediated cytotoxicity on the 20th and 30th postinfection days. Direct cytotoxicity by splenic lymphocytes remained unchanged during infection but antibody dependent cell mediated cytotoxicity was significantly increased.
摘要
研究了从感染蓝氏贾第鞭毛虫的小鼠中分离出的脾、上皮内和固有层淋巴细胞群体对蓝氏贾第鞭毛虫滋养体的直接细胞毒性和抗体依赖性细胞介导的细胞毒性。发现了不同的细胞毒性模式。上皮内淋巴细胞在感染前显示出20.6±5.6%的直接细胞毒性活性。在感染后第20天（p<0.01）和第30天（p<0.05）显著更高。固有层淋巴细胞在感染后第20天和第30天显示出直接细胞毒性和抗体依赖性细胞介导的细胞毒性水平均显著增强。脾淋巴细胞的直接细胞毒性在感染期间保持不变，但抗体依赖性细胞介导的细胞毒性显著增加。
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