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小鼠对蓝氏贾第鞭毛虫感染的获得性抗性。

Acquired resistance to Giardia lamblia infection in mice.

作者信息

Kanwar S S, Ganguly N K, Mahajan R C, Walia B N

出版信息

Trop Geogr Med. 1985 Mar;37(1):32-6.

PMID:4012849
Abstract

The course of Giardia lamblia infection in primary and secondary infection and early and late treated Swiss albino mice was studied. Animals treated after 3 days of infection did not show any resistance to a second challenge, whereas those treated after 9 days did show resistance to reinfection. Reinfected animals eliminated the parasites faster than the other groups. The maximum antibody levels in primary, reinfected, early and late treated groups were observed on the 20th, 10th, 20th and 15th post infection days respectively.

摘要

研究了瑞士白化小鼠在初次和二次感染以及早期和晚期治疗的情况下贾第鞭毛虫感染的病程。感染3天后接受治疗的动物对再次攻击没有表现出任何抵抗力,而感染9天后接受治疗的动物确实对再次感染表现出抵抗力。再次感染的动物比其他组更快地清除了寄生虫。初次感染组、再次感染组、早期治疗组和晚期治疗组的最大抗体水平分别在感染后的第20天、第10天、第20天和第15天观察到。

相似文献

1
Acquired resistance to Giardia lamblia infection in mice.小鼠对蓝氏贾第鞭毛虫感染的获得性抗性。
Trop Geogr Med. 1985 Mar;37(1):32-6.
2
Rapid reinfection by Giardia lamblia after treatment in a hyperendemic Third World community.在一个高度流行的第三世界社区中,贾第虫治疗后快速再次感染。
Lancet. 1988 Feb 13;1(8581):343-5. doi: 10.1016/s0140-6736(88)91131-2.
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Giardia lamblia infection induces different secretory and systemic antibody responses in mice.蓝氏贾第鞭毛虫感染在小鼠中诱导不同的分泌性和全身性抗体反应。
Parasite Immunol. 2005 Sep;27(9):351-6. doi: 10.1111/j.1365-3024.2005.00793.x.
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[Experimental model of activated Lamblia (Giardia) muris infection in albino mice].[白化小鼠中活化的鼠贾第虫感染的实验模型]
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[Treatment of infections by Entamoeba histolytica and Giardia lamblia with different dosages of 100 mg tinidazole enteric coated tablets (author's transl)].
Bol Chil Parasitol. 1979 Jan-Jun;34(1-2):2-6.
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A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children.一项关于儿童贾第虫病治疗的随机、对照、开放标签试验,比较单日服用甲苯咪唑与单剂量替硝唑的疗效。
Curr Med Res Opin. 2006 Nov;22(11):2131-6. doi: 10.1185/030079906X132497.
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Thymus dependency of host resistance to Giardia muris infection: studies in nude mice.宿主对鼠贾第虫感染抵抗力的胸腺依赖性:在裸鼠中的研究
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Susceptibility of Giardia lamblia trophozoites to the lethal effect of human serum.蓝氏贾第鞭毛虫滋养体对人血清致死效应的敏感性。
J Immunol. 1984 Apr;132(4):2046-52.
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引用本文的文献

1
Resistance to reinfection in mice as a vaccine model for giardiasis.作为贾第虫病疫苗模型的小鼠再感染抗性
Hum Vaccin Immunother. 2014;10(6):1536-43. doi: 10.4161/hv.29116. Epub 2014 May 7.
2
Direct and antibody dependent cell mediated cytotoxicity against Giardia lamblia by splenic and intestinal lymphoid cells in mice.小鼠脾脏和肠道淋巴细胞对蓝氏贾第鞭毛虫的直接及抗体依赖性细胞介导的细胞毒性作用
Gut. 1986 Jan;27(1):73-7. doi: 10.1136/gut.27.1.73.
3
The macrophages as an effector cell in Giardia lamblia infections.巨噬细胞作为蓝氏贾第鞭毛虫感染中的效应细胞。
Med Microbiol Immunol. 1987;176(2):83-8. doi: 10.1007/BF00200679.
4
Infectivity of Swiss Giardia isolates to jirds and mice, and in vitro cultivation of trophozoites originating from sheep.
Parasitol Res. 1987;74(2):103-11. doi: 10.1007/BF00536020.