Mutations of Gene Disturb Innate Immune Response to .

(the fruit fly) is a valuable experimental platform for modeling host-pathogen interactions. It is also commonly used to define innate immunity pathways and to understand the mechanisms of both host tolerance to commensal microbiota and response to pathogenic agents. Herein, we investigate how the host response to bacterial infection is mirrored in the expression of genes of Imd and Toll pathways when strains with different genetic backgrounds are infected with ATCC 27853. Using microarray technology, we have interrogated the whole-body transcriptome of infected versus uninfected fruit fly males with three specific genotypes, namely wild-type Oregon, /TM6B and /. While the expression of genes pertaining to Imd and Toll is not significantly modulated by infection in Oregon males, many of the components of these cascades are up- or downregulated in both infected and uninfected /TM6B and / males. Thus, our results suggest that a genetic background modulates the gene expression profiles of Imd and Toll cascades involved in the innate immune response of inducing the occurrence of immunological dysfunctions in mutants.