Histocell S.L., Bizkaia Science and Technology Park, 48160 Derio, Spain.
Department of Medicine and Medical Specialties, Faculty of Medicine, Alcalá de Henares University, 28805 Madrid, Spain.
Int J Mol Sci. 2022 Jun 10;23(12):6538. doi: 10.3390/ijms23126538.
The identification of compounds and natural ingredients that can counteract tissue stress and dysfunction induced by aging in skin cells is warranted. Here, we investigated the activity of the secretion from the snail (SCA), an active compound with well-established beneficial effects on skin integrity and aging. To determinate its senescence-regulation mechanisms, we used a model where damage was induced by hydrogen peroxide (HO). The results showed that SCA positively modulated factors involved in cell senescence such as β-galactosidase and cell morphology, secretory efficiency markers (SIRT1/6 and carboxymethyl-lysine), and metabolic and redox homeostasis (mTOR and ROS). This study demonstrated a novel compound that is activity-modulating, reduces cell senescence, and increases longevity to maintain skin homeostasis and functionality.
有必要鉴定能够对抗皮肤细胞衰老引起的组织应激和功能障碍的化合物和天然成分。在这里，我们研究了蜗牛分泌物 (SCA) 的活性，这是一种对皮肤完整性和衰老具有良好作用的活性化合物。为了确定其衰老调节机制，我们使用了一种由过氧化氢 (HO) 诱导损伤的模型。结果表明，SCA 正向调节细胞衰老相关因子，如β-半乳糖苷酶和细胞形态、分泌效率标志物 (SIRT1/6 和羧甲基赖氨酸) 以及代谢和氧化还原稳态 (mTOR 和 ROS)。这项研究证明了一种新型化合物，它具有活性调节作用，可减少细胞衰老并延长寿命，以维持皮肤的内稳态和功能。
