Scientific Department, Wellcomet GmbH, Karlsruhe, Germany.
Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Bioessays. 2022 Jan;44(1):e2100207. doi: 10.1002/bies.202100207. Epub 2021 Nov 12.
Emerging data connects the aging process in dermal fibroblasts with metabolic reprogramming, provided by enhanced fatty acid oxidation and reduced glycolysis. This switch may be caused by a significant expansion of the dermal white adipose tissue (dWAT) layer in aged, hair-covered skin. Dermal adipocytes cycle through de-differentiation and re-differentiation. As a result, there is a strongly enhanced release of free fatty acids into the extracellular space during the de-differentiation of dermal adipocytes in the catagen phase of the hair follicle cycle. Both caveolin-1 and adiponectin are critical factors influencing these processes. Controlling the expression levels of these two factors also offers the ability to manipulate the metabolic preferences of the different cell types within the microenvironment of the skin, including dermal fibroblasts. Differential expression of adiponectin and caveolin-1 in the various cell types may also be responsible for the cellular metabolic heterogeneity within the cells of the skin.
新兴数据将真皮成纤维细胞的衰老过程与代谢重编程联系起来，这是由增强的脂肪酸氧化和减少的糖酵解提供的。这种转变可能是由于在有毛发覆盖的老年皮肤中，真皮白色脂肪组织 (dWAT) 层的显著扩张引起的。真皮脂肪细胞经历去分化和再分化。结果，在毛囊周期的退行期，真皮脂肪细胞去分化时，细胞外空间中游离脂肪酸的释放强烈增强。窖蛋白-1 和脂联素都是影响这些过程的关键因素。控制这两个因素的表达水平也提供了操纵皮肤微环境中不同细胞类型（包括真皮成纤维细胞）代谢偏好的能力。脂联素和窖蛋白-1在不同细胞类型中的差异表达也可能是皮肤细胞内细胞代谢异质性的原因。
