Malhi P K, Grover I S
Mutat Res. 1987 May;188(1):45-51. doi: 10.1016/0165-1218(87)90113-3.
The genotoxic effects of 4 organophosphorus pesticides, i.e., ekatin, fenitrothion, methylparathion and phorate, were assessed employing in vivo chromosomal aberration bioassay in bone marrow cells in rat. Methylparathion and phorate were found to be mutagenic while ekatin was weakly mutagenic. The frequency of chromosomal aberrations induced by fenitrothion did not differ significantly from that observed in negative control.
采用大鼠骨髓细胞体内染色体畸变生物测定法，评估了4种有机磷农药（即克杀磷、杀螟硫磷、甲基对硫磷和甲拌磷）的遗传毒性。发现甲基对硫磷和甲拌磷具有致突变性，而克杀磷具有弱致突变性。杀螟硫磷诱导的染色体畸变频率与阴性对照中观察到的频率没有显著差异。
