Degraeve N, Chollet M C, Moutschen J
Food Chem Toxicol. 1984 Aug;22(8):683-7. doi: 10.1016/0278-6915(84)90280-1.
Male mice (Q strain) were given a single ip injection at the maximum tolerated dose of one of four commercial mixtures of insecticides: Luxan Tue-Taons (150 g dimethoate and 150 g fenitrothion/litre), Metadipterex (210 g trichlorfon and 270 g methyldemeton/litre), Dynafos (155 g malathion, 60 g dichlorvos and 75 g carbaryl/litre) and Phosan Plus (95 g dimethoate, 100 g malathion and 100 g methoxychlor/litre). At the maximum tolerated doses, Luxan Tue-Taons (60 mg/kg), Metadipterex (15 mg/kg), Dynafos (50 mg/kg) and Phosan Plus (100 mg/kg) did not induce chromosome aberrations in bone-marrow cells, spermatogonia or primary spermatocytes of the mice. No evidence of potential genetic effects was obtained in a dominant lethal mutation assay.
给雄性Q品系小鼠腹腔注射四种市售杀虫剂混合物之一，剂量为最大耐受剂量：乐杀螨（敌百虫150克和杀螟硫磷150克/升）、甲基毒虫畏（敌百虫210克和甲基内吸磷270克/升）、达纳福斯（马拉硫磷155克、敌敌畏60克和西维因75克/升）以及福杀松加强剂（敌百虫95克、马拉硫磷100克和甲氧滴滴涕100克/升）。在最大耐受剂量下，乐杀螨（60毫克/千克）、甲基毒虫畏（15毫克/千克）、达纳福斯（50毫克/千克）和福杀松加强剂（100毫克/千克）均未在小鼠骨髓细胞、精原细胞或初级精母细胞中诱导染色体畸变。在显性致死突变试验中未获得潜在遗传效应的证据。
