Zieleniewska Natalia Anna, Kazberuk Małgorzata, Chlabicz Małgorzata, Eljaszewicz Andrzej, Kamiński Karol
Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Białystok, 15-259 Bialystok, Poland.
Department of Cardiology, Teaching University Hospital of Białystok, 15-259 Bialystok, Poland.
J Clin Med. 2022 Jun 12;11(12):3369. doi: 10.3390/jcm11123369.
Atherosclerosis remains the leading cause of cardiovascular diseases and represents a primary public health challenge. This chronic state may lead to a number of life-threatening conditions, such as myocardial infarction and stroke. Lipid metabolism alterations and inflammation remain at the forefront of the pathogenesis of atherosclerotic cardiovascular disease, but the overall mechanism is not yet fully understood. Recently, significant effects of trained immunity on atherosclerotic plaque formation and development have been reported. An increased reaction to restimulation with the same stimulator is a hallmark of the trained innate immune response. The impact of trained immunity is a prominent factor in both acute and chronic coronary syndrome, which we outline in this review.
动脉粥样硬化仍然是心血管疾病的主要原因，是一项重大的公共卫生挑战。这种慢性状态可能导致许多危及生命的情况，如心肌梗死和中风。脂质代谢改变和炎症仍然是动脉粥样硬化性心血管疾病发病机制的首要因素，但总体机制尚未完全明确。最近，有报道称训练有素的免疫对动脉粥样硬化斑块的形成和发展有显著影响。对同一刺激物再次刺激的反应增强是训练有素的先天免疫反应的一个标志。训练有素的免疫的影响是急性和慢性冠状动脉综合征的一个突出因素，我们将在本综述中概述这一点。
