Department of Surgery, University of Turku, Turku, Finland.
Division of Gastroenterology and Urology, Department of Vascular Surgery, Turku University Hospital, Turku, Finland.
Clin Transl Sci. 2024 Oct;17(10):e70036. doi: 10.1111/cts.70036.
Aortic calcification-a marker of advanced atherosclerosis in large arteries-associates with cardiovascular mortality and morbidity. Little is known about the soluble inflamJarmatory profiles involved in large artery atherosclerosis. We investigated the correlation between aortic calcification in the abdominal aorta and cytokine levels in a cohort of peripheral artery disease patients. Aortic calcification index was measured from computed tomography exams and circulating cytokine levels were analyzed from blood serum samples of 156 consecutive patients prior to invasive treatment of peripheral artery disease. The study included 156 patients (mean age 70.7 years, 64 (41.0%) women). The mean ankle-brachial index (ABI) was 0.64 and the mean aortic calcification index (ACI) was 52.3. ACI was associated with cytokines cutaneous T-cell-attracting chemokine CTACK (β 23.08, SE 5.22, p < 0.001) and monokine induced by gamma-interferon MIG (β 9.40, SE 2.82, p 0.001) in univariate linear regression. After adjustment with cardiovascular risk factors, CTACK and MIG were independently associated with ACI, β 17.9 (SE 5.22, p < 0.001) for CTACK and β 6.80 (SE 3.33, p 0.043) for MIG. CTACK was significantly higher in the patients representing the highest ACI tertile (highest vs. middle, 7.53 vs. 7.34 Tukeys HSD p-value 0.023 and highest vs. lowest tertile 7.53 vs. 7.29, Tukeys HSD p-value 0.002). MIG was significantly higher in the highest tertile versus lowest (7.65 vs. 7.30, Tukeys HSD p-value 0.027). Cytokines CTACK and MIG are associated with higher ACI, suggesting that CTACK and MIG reflect atherosclerotic disease burden of the aorta. This might further suggest the possible association with other cardiovascular morbidities.
腹主动脉钙化——大动脉粥样硬化的一个标志——与心血管死亡率和发病率相关。关于涉及大动脉粥样硬化的可溶性炎症谱知之甚少。我们研究了腹主动脉钙化与外周动脉疾病患者队列中细胞因子水平之间的相关性。从计算机断层扫描检查中测量主动脉钙化指数，并从 156 例连续接受外周动脉疾病侵入性治疗的患者的血清样本中分析循环细胞因子水平。该研究包括 156 例患者（平均年龄 70.7 岁，64 例（41.0%）为女性）。平均踝肱指数（ABI）为 0.64，平均主动脉钙化指数（ACI）为 52.3。ACI 与细胞因子皮肤 T 细胞吸引趋化因子 CTACK（β 23.08，SE 5.22，p<0.001）和γ干扰素诱导的单核细胞趋化因子 MIG（β 9.40，SE 2.82，p<0.001）呈正相关在单变量线性回归中。在调整心血管危险因素后，CTACK 和 MIG 与 ACI 独立相关，CTACK 的β为 17.9（SE 5.22，p<0.001），MIG 的β为 6.80（SE 3.33，p=0.043）。在代表 ACI 最高三分位的患者中，CTACK 明显更高（最高与中间三分位相比，7.53 比 7.34 Tukeys HSD p 值 0.023，最高与最低三分位相比，7.53 比 7.29，Tukeys HSD p 值 0.002）。MIG 在最高三分位与最低三分位之间的差异也有统计学意义（7.65 比 7.30，Tukeys HSD p 值 0.027）。细胞因子 CTACK 和 MIG 与较高的 ACI 相关，提示 CTACK 和 MIG 反映了主动脉粥样硬化疾病负担。这可能进一步表明与其他心血管疾病发病率的可能关联。
