Sisto Margherita, Ribatti Domenico, Lisi Sabrina
Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari "Aldo Moro", I-70124 Bari, Italy.
J Clin Med. 2022 Jun 20;11(12):3551. doi: 10.3390/jcm11123551.
Sjögren's syndrome (SS) is a systemic chronic autoimmune disorder characterized by lymphoplasmacytic infiltration of salivary glands (SGs) and lacrimal glands, causing glandular damage. The disease shows a combination of dryness symptoms found in the oral cavity, pharynx, larynx, and vagina, representing a systemic disease. Recent advances link chronic inflammation with SG fibrosis, based on a molecular mechanism pointing to the epithelial to mesenchymal transition (EMT). The continued activation of inflammatory-dependent fibrosis is highly detrimental and a common final pathway of numerous disease states. The important question of whether and how fibrosis contributes to SS pathogenesis is currently intensely debated. Here, we collect the recent findings on EMT-dependent fibrosis in SS SGs and explore clinical evidence of multi-organ fibrosis in SS to highlight potential avenues for therapeutic investigation.
干燥综合征（SS）是一种全身性慢性自身免疫性疾病，其特征是唾液腺（SGs）和泪腺出现淋巴细胞和浆细胞浸润，导致腺体损伤。该疾病表现为口腔、咽部、喉部和阴道出现干燥症状，是一种全身性疾病。基于上皮-间质转化（EMT）的分子机制，最近的研究进展将慢性炎症与SG纤维化联系起来。炎症依赖性纤维化的持续激活非常有害，是许多疾病状态的共同最终途径。纤维化是否以及如何促成SS发病机制这一重要问题目前正在激烈辩论中。在这里，我们收集了关于SS SGs中EMT依赖性纤维化的最新研究结果，并探讨了SS中多器官纤维化的临床证据，以突出治疗研究的潜在途径。
