Department of Oral and Maxillofacial Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos, Switzerland.
Medicina (Kaunas). 2022 Jun 9;58(6):778. doi: 10.3390/medicina58060778.
: The objective of this study was to evaluate the effects of bisphosphonate (BP) administration on tooth growth, using CT-data of a minipig animal model investigation. : Tooth growth was evaluated in minipigs, with eight animals receiving weekly zoledronate (ZOL) and three animals serving as the control group. Tooth growth was evaluated at the right 2nd molar (M2) in the maxilla. A computed tomography-based measuring method was applied to evaluate tooth growth in the coronal-apical, buccal-oral and mesial-distal axis. : ZOL-administration was found to impact tooth growth in all evaluated measuring axes, with the highest effect observed in the coronal-apical axis. : Detrimental effects of BP administration on growing teeth have been reported by a number of investigators. The results of this investigation demonstrate that intravenous ZOL affects the growth of the whole tooth within a short period of administration. With BPs being administered to a growing number of pediatric patients, further studies should be conducted to qualify and quantify the effects of BPs on developing teeth.
: 本研究旨在通过小型猪动物模型研究，利用 CT 数据评估双膦酸盐（BP）给药对牙齿生长的影响。 : 在接受每周唑来膦酸（ZOL）治疗的 8 只动物和作为对照组的 3 只动物中评估牙齿生长情况。在上颌右侧第二磨牙（M2）评估牙齿生长情况。采用基于计算机断层扫描的测量方法，评估牙冠-根尖、颊舌和近远中轴的牙齿生长情况。 : 研究发现，ZOL 给药会影响所有评估测量轴上的牙齿生长，其中在冠根轴上的影响最大。 : 许多研究人员已经报道了 BP 给药对生长中牙齿的有害影响。本研究结果表明，静脉内 ZOL 在给药的短时间内会影响整个牙齿的生长。随着越来越多的儿科患者接受 BP 治疗，应进行进一步的研究，以确定和量化 BP 对发育中牙齿的影响。
