Department of Family Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
2nd Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Medicina (Kaunas). 2022 Jun 9;58(6):780. doi: 10.3390/medicina58060780.
Psoriasis is a complex disease with many associated comorbidities, all of which have a negative impact on a patient's personal, social, and sexual life. There are some unique considerations in the effects of this disease among women. The average age of diagnosis in women with psoriasis is 28 years, and this onset corresponds to the fertile life of women. There is conflicting information about the effects of psoriasis on female fertility. Some studies suggest that this condition's associated comorbidities, personal behaviors, and reduced ovarian reserve, especially due to chronic inflammation, affect women's fertility. Another possible reason women with psoriasis are less likely to become pregnant is that their sexual intercourse frequency decreases after the condition's onset. The available information on the effects of pregnancy on women with psoriasis is limited. According to current evidence, most women will experience an improvement in their skin condition. Studies show that patients with moderate-to-severe psoriasis are more prone to experience pregnancy complications. The management of pregnant and lactating women with psoriasis is also difficult, as the safety profile of commonly used drugs in patients with psoriasis is not entirely known.
银屑病是一种复杂的疾病，伴有许多相关的合并症，所有这些都会对患者的个人、社交和性生活产生负面影响。在女性中，这种疾病的影响有一些独特的考虑因素。女性银屑病的平均诊断年龄为 28 岁，而这个发病年龄与女性的生育期相对应。关于银屑病对女性生育能力的影响存在相互矛盾的信息。一些研究表明，这种疾病相关的合并症、个人行为以及卵巢储备减少，尤其是由于慢性炎症，会影响女性的生育能力。另一个可能导致银屑病女性怀孕几率降低的原因是，她们在发病后性交频率下降。目前关于妊娠对银屑病女性影响的信息有限。根据现有证据，大多数女性的皮肤状况会有所改善。研究表明，中重度银屑病患者更易出现妊娠并发症。患有银屑病的孕妇和哺乳期妇女的管理也很困难，因为在患者中常用药物的安全性概况并不完全清楚。
