Burlando Martina, Salvi Ilaria, Poddine Gabriele, Cozzani Emanuele, Parodi Aurora
Section of Dermatology, DISSAL, University of Genoa, Ospedale-Policlinico San Martino, IRCCS, Genova, Italy.
Dermatol Pract Concept. 2024 Oct 30;14(4):e2024221. doi: 10.5826/dpc.1404a221.
Approximately half of patients affected by psoriasis are women, and the management of female patients of childbearing age is an under-investigated topic. Some studies have shown a significant decrease in births in psoriatic patients due to intimacy and pregnancy avoidance and to potential birth complications.
We sought to evaluate data on reproductive health in a cohort of female patients, to compare them with similar data in the general population and to assess the impact of psoriasis, especially genital psoriasis, on pregnancy desire and the prevalence of psoriasis in the children of patients with psoriasis.
This retrospective observational study involved adult female patients with a diagnosis of psoriasis made during or before childbearing age. The enrolled patients were asked questions concerning fertility and previous pregnancies in relation to their dermatologic disease.
Of 100 women enrolled, 73 reported a history of pregnancy, for a total of 170 pregnancies. The average number of pregnancies to term and the average number of children per woman (1.2 ± 1) were lower than the national average. The percentage of miscarriages was 18.2%, higher than the national average; in particular, women with psoriatic arthritis had a greater percentage of miscarriages (27.4%). During the pregnancies, psoriasis was mainly stable (36.1%) or improved (29.2%), even though most patients (91.5%) did not follow any treatment.
Psoriasis impacts pregnancy desire and course. The management of psoriasis in women of childbearing age is crucial to minimize its burden on this vulnerable population.
约半数银屑病患者为女性，育龄期女性患者的管理是一个研究不足的话题。一些研究表明，银屑病患者因亲密关系及避免怀孕和潜在的分娩并发症导致生育显著减少。
我们试图评估一组女性患者的生殖健康数据，将其与普通人群的类似数据进行比较，并评估银屑病，尤其是生殖器银屑病，对怀孕意愿以及银屑病患者子女中银屑病患病率的影响。
这项回顾性观察性研究纳入了在育龄期或之前被诊断为银屑病的成年女性患者。就其皮肤病询问了登记患者有关生育能力和既往妊娠的问题。
在登记的100名女性中，73名有妊娠史，妊娠总数为170次。足月妊娠的平均次数及每名女性的平均子女数（1.2±1）低于全国平均水平。流产率为18.2%，高于全国平均水平；特别是银屑病关节炎女性的流产率更高（27.4%）。在妊娠期间，银屑病主要处于稳定状态（36.1%）或有所改善（29.2%），尽管大多数患者（91.5%）未接受任何治疗。
银屑病会影响怀孕意愿和妊娠过程。育龄期女性银屑病的管理对于将其对这一弱势群体的负担降至最低至关重要。
