Department of Surgical Education, Wroclaw Medical University, ul. Sklodowskiej-Curie 66, 50-369 Wroclaw, Poland.
Department of Biochemistry, Wroclaw Medical University, Wroclaw, Poland.
Cell Mol Biol Lett. 2020 Jun 9;25:35. doi: 10.1186/s11658-020-00228-7. eCollection 2020.
One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in rapidly dividing cancer cells are closely associated with increased uptake of glucose and abnormal activity of lactate dehydrogenase (LDH), which regulates the processing of glucose to lactic acid. As serum LDH levels were found to be commonly increased in cancer patients and correlated with poor clinical outcome and resistance to therapy, the determination of LDH has become a standard supportive tool in diagnosing cancers or monitoring the effects of cancer treatment. The aim of this review is to summarize the current knowledge about methods and the practical utility for measuring both the total LDH and LDH isoenzymatic activities in the diagnosis, prognosis and prediction of cancer diseases.
癌细胞的一个特征是与细胞增殖活性较高相关的能量需求增加。快速分裂的癌细胞中的代谢变化与葡萄糖摄取增加和乳酸脱氢酶 (LDH) 的异常活性密切相关，LDH 调节葡萄糖向乳酸的转化。由于发现血清 LDH 水平在癌症患者中普遍升高，并与不良临床结局和对治疗的耐药性相关，因此 LDH 的测定已成为诊断癌症或监测癌症治疗效果的标准辅助工具。本综述的目的是总结目前关于测量总 LDH 和 LDH 同工酶活性在癌症诊断、预后和预测中的方法和实际应用的知识。
