双滤过血浆置换后人组织中水分性质的变化——病例研究。

Changes in Water Properties in Human Tissue after Double Filtration Plasmapheresis-A Case Study.

机构信息

Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.

Aquaphotomics Research Department, Graduate School of Agricultural Science, Kobe University, Kobe 657-8501, Japan.

出版信息

Molecules. 2022 Jun 20;27(12):3947. doi: 10.3390/molecules27123947.

DOI:10.3390/molecules27123947

PMID:35745071

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9230951/

Abstract

Double-filtration plasmapheresis (DFPP) is a blood cleaning technique that enables the removal of unwanted substances from the blood. In our case study, we performed near-infrared (NIR) spectroscopy measurements on the human hand tissue before and after a specific DFPP treatment (INUSpheresis with a TKM58 filter), along with NIR measurements of the substances extracted via DFPP (eluate). The spectral data were analyzed using the aquaphotomics approach. The analysis showed that the water properties in the tissue change after DFPP treatment, i.e., an increase in small water clusters, free water molecules and a decrease in hydroxylated water as well as superoxide in hydration shells was noted. The opposite effect was observed in the eluates of both DFPP treatments. Our study is the first that documents changes in water spectral properties after DFPP treatments in human tissue. The changes in tissue water demonstrated by our case study suggest that the positive physiological effects of DFPP in general, and of INUSpheresis with the TKM58 filter in particular, may be associated with improvements in water quality in blood and tissues.

摘要

双重滤过血浆置换（DFPP）是一种血液净化技术，可清除血液中的有害物质。在我们的案例研究中，我们在进行特定的 DFPP 治疗（使用 TKM58 过滤器的 INUSpheresis）前后对人体手部组织进行了近红外（NIR）光谱测量，并对通过 DFPP 提取的物质（洗脱液）进行了 NIR 测量。使用 aquaphotomics 方法分析了光谱数据。分析表明，DFPP 治疗后组织中的水性质发生了变化，即注意到小水簇、自由水分子的增加以及水合壳中羟基化水和超氧化物的减少。两种 DFPP 处理的洗脱液都观察到了相反的效果。我们的研究首次记录了 DFPP 治疗后人体组织中水的光谱性质变化。我们的案例研究中显示的组织水变化表明，DFPP 治疗的积极生理效应，特别是使用 TKM58 过滤器的 INUSpheresis 的积极生理效应，可能与血液和组织中水质的改善有关。