Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Molecules. 2022 Jun 20;27(12):3956. doi: 10.3390/molecules27123956.
Neuropathic pain is a chronic pain caused by tissue injury or disease involving the somatosensory nervous system, which seriously affects the patient's body function and quality of life. At present, most clinical medications for the treatment of neuropathic pain, including antidepressants, antiepileptic drugs, or analgesics, often have limited efficacy and non-negligible side effects. As a bioactive and therapeutic component extracted from Chinese herbal medicine, the role of the effective compounds in the prevention and treatment of neuropathic pain have gradually become a research focus to explore new analgesics. Notably, saponins have shown analgesic effects in a large number of animal models. In this review, we summarized the most updated information of saponins, related to their analgesic effects in neuropathic pain, and the recent progress on the research of therapeutic targets and the potential mechanisms. Furthermore, we put up with some perspectives on future investigation to reveal the precise role of saponins in neuropathic pain.
神经病理性疼痛是一种由躯体感觉神经系统损伤或疾病引起的慢性疼痛，严重影响患者的身体功能和生活质量。目前，大多数用于治疗神经病理性疼痛的临床药物，包括抗抑郁药、抗癫痫药或镇痛药，往往疗效有限，且具有不可忽视的副作用。作为一种从中药中提取的生物活性和治疗成分，有效化合物在预防和治疗神经病理性疼痛方面的作用逐渐成为探索新的镇痛药的研究重点。值得注意的是，皂苷在大量动物模型中表现出镇痛作用。在本综述中，我们总结了皂苷的最新信息，包括它们在神经病理性疼痛中的镇痛作用，以及治疗靶点和潜在机制的最新研究进展。此外，我们提出了一些对未来研究的看法，以揭示皂苷在神经病理性疼痛中的精确作用。
