饮食诱导的炎症及其与伊朗人群肌肉减少症的关联：一项病例对照研究。

Diet-induced inflammation and its association with sarcopenia in an Iranian population: a case-control study.

作者信息

Heidarzadeh-Esfahani Neda, Eskandarzadeh Sevda, Mahmoodi Marzieh, Makhtoomi Maede, Alavi Seyyed Mohammad, Shateri Zainab, Nasimi Nasrin, Nouri Mehran, Dabbaghmanesh Mohammad Hossein

机构信息

Department of Nutrition, Iranian Cancer Control Center (MACSA) - Isfahan Branch, Isfahan, Iran.

Nutritional Sciences Department, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

J Health Popul Nutr. 2025 May 31;44(1):182. doi: 10.1186/s41043-025-00942-y.

DOI:10.1186/s41043-025-00942-y

PMID:40450377

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12125811/

Abstract

BACKGROUND

Dietary intake, as one of the critical lifestyle risk factors, plays a crucial role in the risk of sarcopenia, potentially due to its anti-inflammatory properties. The objective of this study was to evaluate the association between the Dietary Inflammatory Index (DII) and the Dietary Inflammatory Score (DIS) with sarcopenia in an Iranian population.

METHODS

In the present study, 80 participants with sarcopenia were included in the case group, and 80 non-sarcopenia participants were included in the control group, matched by gender. Sarcopenia was diagnosed according to the Asian Working Group on Sarcopenia (AWGS) guidelines. Additionally, dietary data obtained from a food frequency questionnaire were used to calculate participants' DIS and DII scores. The association between the DII and DIS and the odds ratio of sarcopenia was assessed by logistic regression in both crude and adjusted models.

RESULTS

In the crude model, the odds of sarcopenia were significantly higher for each unit increase in DIS and DII scores (DIS: odds ratio (OR) = 1.221, 95% confidence interval (CI): 1.128-1.322; DII: OR = 1.271, 95% CI: 1.041-1.553). After adjusting for age, energy, and protein intake, higher odds of sarcopenia were observed for each unit increase in DIS score (OR = 1.129, 95% CI: 1.004-1.268). Similarly, higher odds of sarcopenia were seen for each unit increase in DII score after adjusting for potential confounders (OR = 1.269, 95% CI: 1.032-1.561).

CONCLUSIONS

In conclusion, this study found that greater adherence to the DII and DIS was associated with higher odds of sarcopenia in older adults.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

背景

饮食摄入作为关键的生活方式风险因素之一，可能因其抗炎特性在肌肉减少症风险中起关键作用。本研究的目的是评估伊朗人群中饮食炎症指数（DII）和饮食炎症评分（DIS）与肌肉减少症之间的关联。

方法

在本研究中，病例组纳入了80名肌肉减少症患者，对照组纳入了80名非肌肉减少症参与者，并按性别进行匹配。根据亚洲肌肉减少症工作组（AWGS）指南诊断肌肉减少症。此外，从食物频率问卷中获得的饮食数据用于计算参与者的DIS和DII分数。在粗模型和调整模型中，通过逻辑回归评估DII和DIS与肌肉减少症的比值比。

结果

在粗模型中，DIS和DII分数每增加一个单位，肌肉减少症的几率显著更高（DIS：比值比（OR）=1.221，95%置信区间（CI）：1.128 - 1.322；DII：OR = 1.271，95% CI：1.041 - 1.553）。在调整年龄、能量和蛋白质摄入量后，DIS分数每增加一个单位，观察到肌肉减少症的几率更高（OR = 1.129，95% CI：1.004 - 1.268）。同样，在调整潜在混杂因素后，DII分数每增加一个单位，肌肉减少症的几率也更高（OR = 1.269，95% CI：1.032 - 1.561）。