Molchanov Vyacheslav S, Shibaev Andrey V, Karamov Eduard V, Larichev Viktor F, Kornilaeva Galina V, Fedyakina Irina T, Turgiev Ali S, Philippova Olga E, Khokhlov Alexei R
Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia.
Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health, 123098 Moscow, Russia.
Polymers (Basel). 2022 Jun 16;14(12):2444. doi: 10.3390/polym14122444.
Antiseptic polymer gel-surfactant complexes were prepared by incorporating the low-molecular-weight cationic disinfectant cetylpyridinium chloride into the oppositely charged, slightly cross-linked polymer matrices. Three types of polymers were used: copolymers of acrylamide and sodium 2-acrylamido-2-methylpropane sulfonate; copolymers of acrylamide and sodium methacrylate; copolymers of vinylpyrrolidone and sodium methacrylate. It was shown that the rate of the release of the cationic disinfectant from the oppositely charged polymer gels could be tuned in a fairly broad range by varying the concentration of the disinfectant, the degree of swelling, and degree of cross-linking of the gel and the content/type of anionic repeat units in the polymer matrix. Polymer-surfactant complexes were demonstrated to reduce SARS-CoV-2 titer by seven orders of magnitude in as little as 5 s. The complexes retained strong virucidal activity against SARS-CoV-2 for at least one week.
通过将低分子量阳离子消毒剂十六烷基吡啶氯化物掺入带相反电荷的轻度交联聚合物基质中，制备了抗菌聚合物凝胶-表面活性剂复合物。使用了三种类型的聚合物：丙烯酰胺与2-丙烯酰胺基-2-甲基丙烷磺酸钠的共聚物；丙烯酰胺与甲基丙烯酸钠的共聚物；乙烯基吡咯烷酮与甲基丙烯酸钠的共聚物。结果表明，通过改变消毒剂的浓度、溶胀度、凝胶的交联度以及聚合物基质中阴离子重复单元的含量/类型，可以在相当宽的范围内调节阳离子消毒剂从带相反电荷的聚合物凝胶中的释放速率。聚合物-表面活性剂复合物被证明在短短5秒内就能将SARS-CoV-2滴度降低7个数量级。这些复合物对SARS-CoV-2至少保持一周的强大杀病毒活性。
