Knopman D S, Nissen M J
Neurology. 1987 May;37(5):784-8. doi: 10.1212/wnl.37.5.784.
The purpose of the present study was to determine whether patients with probable Alzheimer's disease (AD) were capable of implicit procedural learning. AD patients and elderly control subjects were given a serial visual reaction time task with an embedded repeating sequence. The AD patients responded more slowly than the controls, but many nonetheless showed learning of the repeating sequence. Patients who failed to learn the sequence were similar in age and overall severity of dementia to those who learned, but they scored lower on some tasks of nonverbal reasoning.
本研究的目的是确定可能患有阿尔茨海默病(AD)的患者是否具备内隐程序性学习能力。对AD患者和老年对照受试者进行了一项包含重复序列的连续视觉反应时任务。AD患者的反应比对照组慢,但许多患者仍表现出对重复序列的学习。未能学会该序列的患者在年龄和痴呆症总体严重程度方面与学会的患者相似,但他们在一些非语言推理任务上得分较低。