Milner-Brown H S, Mellenthin M, Sharma M L, Miller R G
Neurology. 1987 May;37(5):800-3. doi: 10.1212/wnl.37.5.800.
In 10 patients with myasthenia gravis, we studied the relationship between plasma pyridostigmine levels and five measures of neuromuscular function (NMF) following single oral doses of 60 to 120 mg. The NMF measures were percent decrement of the evoked muscle compound potential, maximum force, force-time integral, vital capacity, and outstretched-arm time. The combined mean improvement was most significant 2 hours after pyridostigmine ingestion and coincided with the peak plasma pyridostigmine levels in eight patients. In seven patients, there was a positive correlation between plasma pyridostigmine levels and the mean percent improvement.
在10例重症肌无力患者中，我们研究了单次口服60至120毫克吡啶斯的明后血浆吡啶斯的明水平与五项神经肌肉功能（NMF）指标之间的关系。NMF指标包括诱发肌肉复合电位的递减百分比、最大肌力、肌力-时间积分、肺活量和伸臂时间。联合平均改善在摄入吡啶斯的明后2小时最为显著，并且在8例患者中与血浆吡啶斯的明水平峰值一致。在7例患者中，血浆吡啶斯的明水平与平均改善百分比之间存在正相关。
