Turan U, Kilavuz H, Irkorucu O
Adana City Training and Research Hospital, Department of General Surgery, Adana, Turkey.
University of Sharjah, College of Medicine, Clinical Sciences Department, Sharjah, United Arab Emirates.
Acta Endocrinol (Buchar). 2021 Oct-Dec;17(4):493-497. doi: 10.4183/aeb.2021.493.
Primary hyperparathyroidism related hypercalcemic crisis (PHHC) is a condition that may result in fetal course. So, the early diagnosis and treatment of these patients are important.
This study aimed to investigate the clinical features for hypercalcemic crisis (HC) by comparing the groups with and without primary hyperparathyroidism related calcemic crisis.
All patients operated with primary hyperparathyroidism (PH) diagnosis in a single clinic between March 2015 and March 2020 were included in this retrospective study.
119 patients included the study.Patients with serum calcium (Ca) level > 14 mg/dl were regarded as HC and the patients were divided into two groups as HC and non-HC. These two groups were compared for demographic data, preoperative biochemical parameters, preoperative localization studies, histopathological assessment and postoperative results.
Serum Parathormone (PTH), Ca, Alkaline phosphatase (ALP) and creatinine values among preoperative biochemical parameters were higher in the HC group than the non-HC (p<0.005). The hyper-functional parathyroid size of the patients in the HC group was also bigger compared to non-HC (p<0.05). No difference was observed in the demographic and histopathological data, preoperative localization studies and postoperative results of the two groups (p>0.05).
PH is usually an elective operation and PHCC treatment should be relatively more urgent as it can be mortal. Higher HC occurrence possibility should be considered in PH patients with high serum PTH, ALP and creatinine values and large tumor diameters and those patients should be prioritized for treatment.
原发性甲状旁腺功能亢进相关高钙血症危象（PHHC）是一种可能导致不良胎儿结局的病症。因此，对这些患者进行早期诊断和治疗很重要。
本研究旨在通过比较有和无原发性甲状旁腺功能亢进相关高钙血症危象的两组患者，探讨高钙血症危象（HC）的临床特征。
本回顾性研究纳入了2015年3月至2020年3月期间在单一诊所接受原发性甲状旁腺功能亢进（PH）诊断手术的所有患者。
119例患者纳入研究。血清钙（Ca）水平>14mg/dl的患者被视为HC患者，患者被分为HC组和非HC组。比较这两组患者的人口统计学数据、术前生化参数、术前定位研究、组织病理学评估和术后结果。
术前生化参数中，HC组的血清甲状旁腺激素（PTH）、Ca、碱性磷酸酶（ALP）和肌酐值高于非HC组（p<0.005）。与非HC组相比，HC组患者的功能亢进甲状旁腺大小也更大（p<0.05）。两组患者的人口统计学和组织病理学数据、术前定位研究及术后结果均无差异（p>0.05）。
PH通常是择期手术，而PHCC的治疗应相对更紧急，因为它可能致命。对于血清PTH、ALP和肌酐值高且肿瘤直径大的PH患者，应考虑更高的HC发生可能性，这些患者应优先接受治疗。
