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甲状旁腺腺瘤表现为多发性棕色瘤及严重无症状高钙血症。

PARATHYROID ADENOMA PRESENTING AS MULTIPLE BROWN TUMORS AND SEVERE ASYMPTOMATIC HYPERCALCEMIA.

作者信息

Wasnik D V, Khot R S, Joshi P P, Rathod B D, Narang U, Ratnaparkhi C

机构信息

All India Institute of Medical Sciences - General Medicine, Nagpur, India.

All India Institute of Medical Sciences - Radiodiagnosis, Nagpur, India.

出版信息

Acta Endocrinol (Buchar). 2023 Oct-Dec;19(4):508-511. doi: 10.4183/aeb.2023.508. Epub 2024 Jun 24.

Abstract

INTRODUCTION

Primary hyperparathyroidism may have several presentations, varying from an incidental asymptomatic biochemical finding to gastrointestinal, psychiatric, renal and bone manifestations. Brown tumors are rare non-neoplastic lesions because of abnormal bone metabolism. Herein, we describe a patient who presented with lytic bony lesions and severe asymptomatic hypercalcemia due to parathyroid adenoma.

CASE PRESENTATION

A 38-year-old male presented with multiple painful bony lesions over upper and lower limbs. Radiographs of long bones showed multiple lytic lesions with cortical thinning. Investigations revealed hypercalcemia and hyperparathyroidism. A radionuclide scan showed parathyroid adenoma. The patient was treated for hypercalcemia and a parathyroidectomy was performed.

CONCLUSIONS

In a patient presenting with multiple bony swellings and asymptomatic hypercalcemia, hyperparathyroidism should be suspected. Parathyroid adenoma is a treatable cause of primary hyperparathyroidism.

摘要

引言

原发性甲状旁腺功能亢进可能有多种表现,从偶然的无症状生化检查发现到胃肠道、精神、肾脏和骨骼表现不等。棕色瘤是由于骨代谢异常导致的罕见非肿瘤性病变。在此,我们描述一名因甲状旁腺腺瘤出现溶骨性骨病变和严重无症状高钙血症的患者。

病例报告

一名38岁男性,上肢和下肢出现多处疼痛性骨病变。长骨X线片显示多处溶骨性病变伴皮质变薄。检查发现高钙血症和甲状旁腺功能亢进。放射性核素扫描显示甲状旁腺腺瘤。该患者接受了高钙血症治疗并进行了甲状旁腺切除术。

结论

对于出现多处骨肿胀和无症状高钙血症的患者,应怀疑甲状旁腺功能亢进。甲状旁腺腺瘤是原发性甲状旁腺功能亢进的可治疗病因。

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Primary hyperparathyroidism.原发性甲状旁腺功能亢进症。
Nat Rev Endocrinol. 2018 Feb;14(2):115-125. doi: 10.1038/nrendo.2017.104. Epub 2017 Sep 8.
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A case of multiple brown tumors with primary hyperparathyroidism.一例原发性甲状旁腺功能亢进伴多发性棕色瘤。
J Bone Miner Metab. 2013 Jan;31(1):123-7. doi: 10.1007/s00774-012-0364-2. Epub 2012 Jun 20.
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Laboratory screening for hyperparathyroidism.
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